ArticleGenes & development2013
Four pillars of the S-phase checkpoint.
Article in Genes & development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Dpb11 facilitates the colocalization of Mec1-Ddc2 with its activators on gapped DNA.Cell reports · 2026Article
- Molecular interplay between the DNA damage checkpoint kinase Mec1-Ddc2 and its activator Dpb11 on gapped DNA.bioRxiv : the preprint server for biology · 2025Article
- Mechanisms of loading and release of the 9-1-1 checkpoint clamp.Nature structural & molecular biology · 2022Article
- Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.Molecular biology of the cell · 2021Article
- Review
- DNA damage kinase signaling: checkpoint and repair at 30 years.The EMBO journal · 2019Review
- Replication protein A (RPA) sumoylation positively influences the DNA damage checkpoint response in yeast.The Journal of biological chemistry · 2019Article
- Structural studies of RFCEMBO reports · 2017Article
- RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.Current biology : CB · 2016Article
- Chromosome Duplication in Saccharomyces cerevisiae.Genetics · 2016Review
- A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.Nucleic acids research · 2015Article
- Chromatin remodeling factors Isw2 and Ino80 regulate checkpoint activity and chromatin structure in S phase.Genetics · 2015Article
- Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex.Genes & development · 2015Article
- Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall.Molecular cell · 2014Article
- Genetic instability is prevented by Mrc1-dependent spatio-temporal separation of replicative and repair activities of homologous recombination: homologous recombination tolerates replicative stress by Mrc1-regulated replication and repair activities operating at S and G2 in distinct subnuclear compartments.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
- Genotoxic stress prevents Ndd1-dependent transcriptional activation of G2/M-specific genes in Saccharomyces cerevisiae.Molecular and cellular biology · 2014Article
- Dna2 is involved in CA strand resection and nascent lagging strand completion at native yeast telomeres.The Journal of biological chemistry · 2013Article
- Clamping down on mammalian meiosis.Cell cycle (Georgetown, Tex.) · 2013Article
- An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.PLoS genetics · 2013Article
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1 author.
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Abstract
The yeast Mec1 kinase is a key regulator of the DNA damage response (DDR). In this issue of Genes & Development, Kumar and Burgers (pp. 313-321) report that Ddc1, Dpb11, and Dna2 function in concert to activate Mec1 during S phase of the cell cycle. Furthermore, the Tel1 kinase also contributes to the DDR in S phase when Mec1 activation is compromised.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.