ReviewCold Spring Harbor perspectives in medicine2013
Hemoglobin variants: biochemical properties and clinical correlates.
Review in Cold Spring Harbor perspectives in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Severe diabetic ketoacidosis unmasking a low-oxygen-affinity haemoglobin variant in an infant: a case report.Acta diabetologica · 2026Article
- First Report of Co-Inheritance of Hemoglobin British Columbia (HBB:c.304G>A) and β-Thalassemia IVS-I-6 (HBB:c.92+6T>C): Clinical Characterization of an Iranian Case.Journal of clinical laboratory analysis · 2026Article
- Validation of Gazelle Microchip Electrophoresis for Premarital Hemoglobinopathy Screening in Türkiye.EJHaem · 2026Article
- Recombinant Hemoglobin rHb0.1 with Cross-Linked Alpha Subunits Preferentially Crystallizes in the βACS omega · 2026Article
- Hemoglobin San Diego: A Case Report and Review of the Literature.The American journal of case reports · 2026Review
- The evolutionary footprint of histidine in hemoglobin and myoglobin: an implication towards their function.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Comparison of point-of-care HbA1c devices with laboratory HPLC methods: A systematic review and meta-analysis.Biomedical reports · 2026Article
- Immersive virtual reality for teaching hemoglobin structure in preclinical medical biochemistry education: a mixed-methods study of student self-reported perceptions.BMC medical education · 2026Article
- A Novel Aberrant HbF Peak with Electrophoretic Shift in A1c of a Patient with Chronic Lymphocytic Leukemia (CLL) Was Reversible to Give Interpretable Results.Biomedicines · 2026Article
- Article
- Common hemoglobin variants affecting the diagnosis of β-thalassemia: A large cohort data at a single center.PloS one · 2026Article
- Acute hemolytic crises and clinical course in a Japanese family with Hb Santander: a detailed case report.International journal of hematology · 2025Article
- A new unstable haemoglobin, Hb Alger, causes a transfusion-dependent anaemia in early childhood.British journal of haematology · 2025Article
- Three cases of hemoglobin M disease in a family lineage: Case report and literature review.Medicine · 2025Review
- Hemoglobin Variants as Targets for Stabilizing Drugs.Molecules (Basel, Switzerland) · 2025Review
- Efficient andMolecular therapy. Nucleic acids · 2024Article
- Links between accuracy and effectiveness of laboratory medicine equipment: use of the EUnetHTA core model to compare two analyzers by measuring HbA1c.International journal of technology assessment in health care · 2024Article
- Functional characterization of compound heterozygosity Hb S/Hb Deer Lodge in Brazil.Hematology, transfusion and cell therapy · 2024Article
- Novel Insights into Hb Shaare Zedek Associated with βInternational journal of molecular sciences · 2024Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Diseases affecting hemoglobin synthesis and function are extremely common worldwide. More than 1000 naturally occurring human hemoglobin variants with single amino acid substitutions throughout the molecule have been discovered, mainly through their clinical and/or laboratory manifestations. These variants alter hemoglobin structure and biochemical properties with physiological effects ranging from insignificant to severe. Studies of these mutations in patients and in the laboratory have produced a wealth of information on hemoglobin biochemistry and biology with significant implications for hematology practice. More generally, landmark studies of hemoglobin performed over the past 60 years have established important paradigms for the disciplines of structural biology, genetics, biochemistry, and medicine. Here we review the major classes of hemoglobin variants, emphasizing general concepts and illustrative examples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.