ArticleCell cycle (Georgetown, Tex.)2013
TD-60 is required for interphase cell cycle progression.
Article in Cell cycle (Georgetown, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
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- Roles of regulator of chromosome condensation 2 in cancer: Beyond its regulatory function in cell cycle.Oncology reviews · 2021Article
- A R2R3-MYB gene-based marker for the non-darkening seed coat trait in pinto and cranberry beans (Phaseolus vulgaris L.) derived from 'Wit-rood boontje'.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Genome-wide identification of loci associated with growth in rainbow trout.BMC genomics · 2020Article
- RCC2 Interacts with Small GTPase RalA and Regulates Cell Proliferation and Motility in Gastric Cancer.OncoTargets and therapy · 2020Article
- RCC2 Expression Stimulates ER-Positive Breast Tumorigenesis.Journal of oncology · 2020Article
- Regulator of Chromosome Condensation 2 Modulates Cell Cycle Progression, Tumorigenesis, and Therapeutic Resistance.Frontiers in molecular biosciences · 2020Review
- Imaging Mass Spectrometry and Proteome Analysis of Marek's Disease Virus-Induced Tumors.mSphere · 2019Article
- Article
- High-performance gene expression and knockout tools using sleeping beauty transposon system.Mobile DNA · 2018Article
- The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells.Scientific reports · 2017Article
- Analysis of Microarray Data on Gene Expression and Methylation to Identify Long Non-coding RNAs in Non-small Cell Lung Cancer.Scientific reports · 2016Article
- TD-60 links RalA GTPase function to the CPC in mitosis.Nature communications · 2015Article
- Melanoma risk loci as determinants of melanoma recurrence and survival.Journal of translational medicine · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We previously identified TD-60 (RCC2) as a mitotic centromere-associated protein that is necessary for proper completion of mitosis. We now report that TD-60 is an essential regulator of cell cycle progression during interphase. siRNA suppression blocks progression of mammalian G₁/S phase cells and progression of G₂ cells into mitosis. Prolonged arrest occurs both in non-transformed cells and in transformed cells lacking functional p53. TD-60 associates with Rac1 and Arf6 and has recently been demonstrated to be an element of α5β1 integrin and cortactin interactomes. These associations with known elements of cell cycle control, together with our data, suggest that TD-60 is an essential component of one or more signaling pathways that drive cell cycle progression. During mitosis, TD-60 is required for correct assembly of the mitotic spindle and activation of key mitotic proteins. In contrast, in interphase TD-60 promotes cell cycle progression through what must be distinct mechanisms. TD-60 thus appears to be one of the growing categories of proteins that "moonlight," or have more than one distinct cellular function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.