SynthesisPublic health nutrition2014
Impact of iron-fortified foods on Hb concentration in children (<10 years): a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Public health nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- A comparative analysis of heme vs non-heme iron administration: a systematic review and meta-analysis of randomized controlled trials.European journal of nutrition · 2024Pooled it
- Fortification of condiments and seasonings with iron for preventing anaemia and improving health.The Cochrane database of systematic reviews · 2023Pooled it
- Fortification of salt with iron and iodine versus fortification of salt with iodine alone for improving iron and iodine status.The Cochrane database of systematic reviews · 2022Pooled it
- Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews.The Cochrane database of systematic reviews · 2021Pooled it
- The Impact of Nutrition-Specific and Nutrition-Sensitive Interventions on Hemoglobin Concentrations and Anemia: A Meta-review of Systematic Reviews.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Systematic review and meta-analysis of the effect of iron-fortified flour on iron status of populations worldwide.Public health nutrition · 2019Pooled it
- Effect of fortified milk on growth and nutritional status in young children: a systematic review and meta-analysis.Public health nutrition · 2017Pooled it
- Evidence of the effectiveness of flour fortification programs on iron status and anemia: a systematic review.Nutrition reviews · 2015Pooled it
- Review
- Spontaneous miscarriage/abortion in the first trimester and expectant management - a meta-analysis approach.Przeglad menopauzalny = Menopause review · 2023Article
- Evaluation of the use of non-invasive hemoglobin measurement in early childhood.Pediatric research · 2023Article
- Impact of milk on malnutrition and cognitive skills among school children: Evidence from gift milk initiative from a tribal state of India.Journal of family medicine and primary care · 2022Article
- Mapping of Health Technology Assessment (HTA) teaching and training initiatives: Landscape for evidence-based policy decisions in India.Journal of family medicine and primary care · 2020Review
- Meta-analysis approach on iron fortification and its effect on pregnancy and its outcome through randomized, controlled trials.Journal of family medicine and primary care · 2020Review
- Maternal and Early Life Iron Intake and Risk of Childhood Type 1 Diabetes: A Danish Case-Cohort Study.Nutrients · 2019Article
- What Approaches are Most Effective at Addressing Micronutrient Deficiency in Children 0-5 Years? A Review of Systematic Reviews.Maternal and child health journal · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo combine evidence from randomized controlled trials to assess the effect of Fe-fortified foods on mean Hb concentration in children (<10 years).
designWe conducted a meta-analysis of randomized, controlled, Fe-fortified feeding trials that evaluated Hb concentration. The weighted mean difference was calculated for net changes in Hb by using random-effects models. Meta-regression and covariate analyses were performed to explore the influence of confounders on the net pooled effect.
settingTrials were identified through a systematic search of PubMed, the Cochrane Library and secondary references. SUBJECTS: Eighteen studies covering 5142 participants were identified. The duration of feeding of fortified foods ranged from 6 to 12 months in these studies.
resultsEighteen studies were included and evaluated in the meta-analysis. The overall pooled estimate of Hb concentration showed a significant increase in the fortification group compared with the control group (weighted mean difference = 5·09 g/l; 95% CI 3·23, 6·95 g/l; I 2 = 90%, τ 2 = 18·37, P < 0·0001). Meta-regression analysis indicated that duration of feeding was positively related to the effect size (regression coefficient = 0·368; 95% CI 0·005, 0·731; P < 0·05). The net pooled effect size after removing the confounders was 4·74 (95% CI 3·08, 6·40) g/l.
conclusionsWe observed an association between intake of Fe-fortified foods and Hb concentration in children aged <10 years. Fe-fortified foods could be an effective strategy for reducing Fe-deficiency anaemia in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.