ArticleBMC complementary and alternative medicine2013
Cytotoxic and apoptotic evaluations of marine bacteria isolated from brine-seawater interface of the Red Sea.
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Extreme Arabian environments and their microbiomes: new frontiers for astrobiology and biosignature discovery.Extremophiles : life under extreme conditions · 2026Review
- Shedding light on the composition of extreme microbial dark matter: alternative approaches for culturing extremophiles.Frontiers in microbiology · 2023Review
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Therapeutic applications and biological activities of bacterial bioactive extracts.Archives of microbiology · 2021Review
- Deep Hypersaline Anoxic Basins as Untapped Reservoir of Polyextremophilic Prokaryotes of Biotechnological Interest.Marine drugs · 2020Review
- Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine.Marine drugs · 2019Review
- Mining the deep Red-Sea brine pool microbial community for anticancer therapeutics.BMC complementary and alternative medicine · 2019Article
- Marine anticancer drugs and their relevant targets: a treasure from the ocean.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Review
- Antibacterial and anticancer activities of orphan biosynthetic gene clusters from Atlantis II Red Sea brine pool.Microbial cell factories · 2019Article
- Supernatant Metabolites from Halophilic Archaea to Reduce Tumorigenesis in Prostate CancerIranian journal of pharmaceutical research : IJPR · 2019Article
- Genome sequence analysis ofBiotechnology reports (Amsterdam, Netherlands) · 2018Article
- Antimicrobial activity of bacteria isolated from Red Sea marine invertebrates.Biotechnology reports (Amsterdam, Netherlands) · 2018Article
- Article
- Antibacterial efficacy of silver nanoparticles and ethyl acetate's metabolites of the potent halophilic (marine) bacterium, Bacillus cereus A30 on multidrug resistant bacteria.Pathogens and global health · 2017Article
- Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity.Applied microbiology and biotechnology · 2017Review
- Bioprospecting Red Sea Coastal Ecosystems for Culturable Microorganisms and Their Antimicrobial Potential.Marine drugs · 2016Article
- A catalogue of 136 microbial draft genomes from Red Sea metagenomes.Scientific data · 2016Article
- Cytotoxic Effects of Tropodithietic Acid on Mammalian Clonal Cell Lines of Neuronal and Glial Origin.Marine drugs · 2015Article
- Induction of apoptosis in cancer cell lines by the Red Sea brine pool bacterial extracts.BMC complementary and alternative medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh salinity and temperature combined with presence of heavy metals and low oxygen renders deep-sea anoxic brines of the Red Sea as one of the most extreme environments on Earth. The ability to adapt and survive in these extreme environments makes inhabiting bacteria interesting candidates for the search of novel bioactive molecules.
methodsTotal 20 i.e. lipophilic (chloroform) and hydrophilic (70% ethanol) extracts of marine bacteria isolated from brine-seawater interface of the Red Sea were tested for cytotoxic and apoptotic activity against three human cancer cell lines, i.e. HeLa (cervical carcinoma), MCF-7 (Breast Adenocarcinoma) and DU145 (Prostate carcinoma).
resultsAmong these, twelve extracts were found to be very active after 24 hours of treatment, which were further evaluated for their cytotoxic and apoptotic effects at 48 hr. The extracts from the isolates P1-37B and P3-37A (Halomonas) and P1-17B (Sulfitobacter) have been found to be the most potent against tested cancer cell lines.
conclusionOverall, bacterial isolates from the Red Sea displayed promising results and can be explored further to find novel drug-like molecules. The cell line specific activity of the extracts may be attributed to the presence of different polarity compounds or the cancer type i.e. biological differences in cell lines and different mechanisms of action of programmed cell death prevalent in different cancer cell lines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.