ArticleBMC genomics2013
An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Benchmarking large language models for identifying transcription factor regulatory interactions.Bioinformatics (Oxford, England) · 2026Article
- Cell-free therapy based on extracellular vesicles: a promising therapeutic strategy for peripheral nerve injury.Stem cell research & therapy · 2023Review
- Recent advances in optical label-free characterization of extracellular vesicles.Nanophotonics (Berlin, Germany) · 2022Review
- Effect of Interleukin-1β on Gene Expression Signatures in Schwann Cells Associated with Neuropathic Pain.Neurochemical research · 2021Article
- Sex-Dependent Changes of miRNA Levels in the Hippocampus of Adrenalectomized Rats Following Acute Corticosterone Administration.ACS chemical neuroscience · 2021Article
- EnhFFL: A database of enhancer mediated feed-forward loops for human and mouse.Precision clinical medicine · 2021Article
- Exosomes: Innocent Bystanders or Critical Culprits in Neurodegenerative Diseases.Frontiers in cell and developmental biology · 2021Review
- A novel fungal gene regulation system based on inducible VPR-dCas9 and nucleosome map-guided sgRNA positioning.Applied microbiology and biotechnology · 2020Article
- Differential gene and protein expression between rat tibial nerve and common peroneal nerve during Wallerian degeneration.Neural regeneration research · 2019Article
- IcarisideII facilitates the differentiation of ADSCs to SCs via let-7i/STAT3 axis to preserve erectile function.Biological research · 2019Article
- Role of miR-9-5p in preventing peripheral neuropathy in patients with rheumatoid arthritis by targeting REST/miR-132 pathway.In vitro cellular & developmental biology. Animal · 2019Article
- MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Therapeutic Strategy.BioMed research international · 2019Review
- Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer.Stem cell research & therapy · 2018Article
- Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration.Neurorehabilitation and neural repair · 2018Review
- Extracellular vesicles and intercellular communication within the nervous system.The Journal of clinical investigation · 2016Review
- Approaches to Peripheral Nerve Repair: Generations of Biomaterial Conduits Yielding to Replacing Autologous Nerve Grafts in Craniomaxillofacial Surgery.BioMed research international · 2016Review
- Transcriptomic Approaches to Neural Repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Review
- Microprocessor complex subunit DiGeorge syndrome critical region gene 8 (Dgcr8) is required for schwann cell myelination and myelin maintenance.The Journal of biological chemistry · 2015Article
- The role of exosomes in peripheral nerve regeneration.Neural regeneration research · 2015Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe regenerative response of Schwann cells after peripheral nerve injury is a critical process directly related to the pathophysiology of a number of neurodegenerative diseases. This SC injury response is dependent on an intricate gene regulatory program coordinated by a number of transcription factors and microRNAs, but the interactions among them remain largely unknown. Uncovering the transcriptional and post-transcriptional regulatory networks governing the Schwann cell injury response is a key step towards a better understanding of Schwann cell biology and may help develop novel therapies for related diseases. Performing such comprehensive network analysis requires systematic bioinformatics methods to integrate multiple genomic datasets.
resultsIn this study we present a computational pipeline to infer transcription factor and microRNA regulatory networks. Our approach combined mRNA and microRNA expression profiling data, ChIP-Seq data of transcription factors, and computational transcription factor and microRNA target prediction. Using mRNA and microRNA expression data collected in a Schwann cell injury model, we constructed a regulatory network and studied regulatory pathways involved in Schwann cell response to injury. Furthermore, we analyzed network motifs and obtained insights on cooperative regulation of transcription factors and microRNAs in Schwann cell injury recovery.
conclusionsThis work demonstrates a systematic method for gene regulatory network inference that may be used to gain new information on gene regulation by transcription factors and microRNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.