ArticleMedical physics2013
4D reconstruction for low-dose cardiac gated SPECT.
Article in Medical physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Pix2Pix generative adversarial network for low dose myocardial perfusion SPECT denoising.Quantitative imaging in medicine and surgery · 2022Article
- Simulating dose reduction for myocardial perfusion SPECT using a Poisson resampling method.Nuclear medicine and molecular imaging · 2021Article
- General simultaneous motion estimation and image reconstruction (G-SMEIR).Biomedical physics & engineering express · 2021Article
- Improving perfusion defect detection with respiratory motion correction in cardiac SPECT at standard and reduced doses.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Personalized Models for Injected Activity Levels in SPECT Myocardial Perfusion Imaging.IEEE transactions on medical imaging · 2019Article
- Investigation of dose reduction in cardiac perfusion SPECT via optimization and choice of the image reconstruction strategy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- The long way to dose reduction in myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Motion-compensated image reconstruction vs postreconstruction correction in respiratory-binned SPECT with standard and reduced-dose acquisitions.Medical physics · 2018Article
- 4D non-local means post-filtering for cardiac gated SPECT.Physics in medicine and biology · 2018Article
- 4-D Reconstruction With Respiratory Correction for Gated Myocardial Perfusion SPECT.IEEE transactions on medical imaging · 2017Article
- Optimizing radiation dose and imaging time with conventional myocardial perfusion SPECT: Technical aspects.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Noise suppressed partial volume correction for cardiac SPECT/CT.Medical physics · 2016Article
- Radiation risk and protection of patients in clinical SPECT/CT.European journal of nuclear medicine and molecular imaging · 2014Review
- Fast spatiotemporal image reconstruction based on low-rank matrix estimation for dynamic photoacoustic computed tomography.Journal of biomedical optics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDue to the combination of high-frequency use and relatively high diagnostic radiation dose (>9 mSv for one scan), there is a need to lower the radiation dose used in myocardial perfusion imaging (MPI) studies in cardiac gated single photon emission computed tomography (GSPECT) in order to reduce its population based cancer risk. The aim of this study is to assess quantitatively the potential utility of advanced 4D reconstruction for GSPECT for significantly lowered imaging dose.
methodsFor quantitative evaluation, Monte Carlo simulation with the 4D NURBS-based cardiac-torso (NCAT) phantom is used for GSPECT imaging at half and quarter count levels in the projections emulating lower injected activity (dose) levels. Both 4D and 3D reconstruction methods are applied at these lowered dose levels, and compared with standard clinical spatiotemporal reconstruction (ST121) at full dose using a number of metrics on the reconstructed images: (1) overall reconstruction accuracy of the myocardium, (2) regional bias-variance analysis of the left ventricle (LV) wall, (3) uniformity of the LV wall, (4) accuracy of the time activity curve (TAC) of the LV wall, and (5) detectability of perfusion defects using channelized Hotelling observer. As a preliminary demonstration, two sets of patient data acquired in list-mode are used to illustrate the conservation of both image quality and LV ejection fraction (LVEF) by 4D reconstruction where only a portion of the acquired counts at each projection angle are used to mimic low-dose acquisitions.
resultsCompared to ST121 at standard dose, even at quarter dose 4D achieved better performance on overall reconstruction accuracy of the myocardium (28.7% improvement on relative root mean square error: standard vs 4D quarter p-value < 10(-30)), regional bias-variance analysis, and similar performance on accuracy of the TAC of the LV wall and detectability of perfusion defects. A slight degradation in uniformity of the LV wall was observed in 4D at quarter dose due to use of scatter correction which increases reconstruction variance. The reconstructed images from simulated and patient data show that 4D at quarter dose is visually comparable to ST121 at standard dose, if not better. Compared to ST121 and 3D, 4D images exhibit less noise artifacts and better definition of the LV wall. The 4D images are also observed to be more consistent between half dose and quarter dose. 4D also yields more consistent LVEF results at different count levels on the patient data.
conclusionsWith various quantitative metrics 4D reconstruction is demonstrated to achieve better or comparable performance at quarter dose (∼2.25 mSv, 75% dose reduction) compared to conventional clinical reconstruction at standard dose (∼9 mSv). Preliminary results from two patient datasets also show that 4D at an equivalent quarter dose can achieve better performance than clinical and 3D methods at higher dose levels. Such a significant dose reduction (75%) has not been demonstrated quantitatively in previous studies in GSPECT. These promising results warrant further investigations on the lower bound of dose reduction with different reconstruction strategies and more comprehensive clinical studies with greater patient variability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.