ArticleInternational journal of burns and trauma2013
Whole body and skeletal muscle protein turnover in recovery from burns.
Article in International journal of burns and trauma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- The effect of active video games on pain intensity, joint range of motion, and motor function in children with burns: a randomized clinical trial.BMC pediatrics · 2025Trial
- Turnover Rates and Numbers of Exchangeable Hydrogens in Deuterated Water Labeled Samples.International journal of molecular sciences · 2025Article
- Metabolic response to burn injury: a comprehensive bibliometric study.Frontiers in medicine · 2024Article
- Clinical Significance of the Prognostic Nutritional Index in Predicting Delirium among Critically Ill Patients: A Retrospective Cohort Study.Critical care research and practice · 2024Article
- Fish Skin Grafts Affect Adenosine and Methionine Metabolism during Burn Wound Healing.Antioxidants (Basel, Switzerland) · 2023Article
- An atlas of protein turnover rates in mouse tissues.Nature communications · 2021Article
- Burn-induced hypermetabolism and skeletal muscle dysfunction.American journal of physiology. Cell physiology · 2021Review
- Acetylation of Phenylalanine Hydroxylase and Tryptophan 2,3-Dioxygenase Alters Hepatic Aromatic Amino Acid Metabolism in Weaned Piglets.Metabolites · 2020Article
- Erythropoietin Alleviates Burn-induced Muscle Wasting.International journal of medical sciences · 2020Article
- Kefir Accelerates Burn Wound Healing Through Inducing Fibroblast Cell Migration In Vitro and Modulating the Expression of IL-1ß, TGF-ß1, and bFGF Genes In Vivo.Probiotics and antimicrobial proteins · 2019Article
- Determinants of skeletal muscle protein turnover following severe burn trauma in children.Clinical nutrition (Edinburgh, Scotland) · 2019Observational
- Burn-Induced Microglia Activation is Associated With Motor Neuron Degeneration and Muscle Wasting in Mice.Shock (Augusta, Ga.) · 2019Article
- Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis.Journal of cachexia, sarcopenia and muscle · 2019Article
- Obesity Alters the Muscle Protein Synthetic Response to Nutrition and Exercise.Frontiers in nutrition · 2019Review
- Body Composition Changes in Severely Burned Children During ICU Hospitalization.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Article
- Respiratory Effects and Systemic Stress Response Following Acute Acrolein Inhalation in Rats.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Stem Cells and Tissue Engineering: Regeneration of the Skin and Its Contents.Clinics in plastic surgery · 2017Review
- A mathematical model for the simulation of the contraction of burns.Journal of mathematical biology · 2017Article
- Satellite cell activation and apoptosis in skeletal muscle from severely burned children.The Journal of physiology · 2016Article
- Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma.American journal of physiology. Endocrinology and metabolism · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Trauma and critical illness are associated with a stress response that results in increased skeletal muscle protein catabolism, which is thought to facilitate the synthesis of acute phase proteins in the liver as well as proteins involved in immune function. What makes burn injury a unique form of trauma is the existence of vast skin lesions, where the majority of afflicted tissue is often surgically excised post injury. Thereafter, recovery is dependent on the formation of a significant quantity of new skin, meaning that the burned patient requires a large and sustained supply of amino acids to facilitate wound healing. Skeletal muscle has the capacity to store surplus glucose and fatty acids within glycogen and triacylglycerol depots respectively, where glycogen and fatty acids can be mobilized during prolonged periods of caloric restriction or heightened metabolic demand (e.g., exercise), to be catabolized in order to maintain cellular ATP availability. Amino acids, on the other hand, are not generally considered to be stored in such a manner within skeletal muscle, i.e., in a temporary pool independent of structural proteins and cellular organelles etc. Subsequently, in response to severe thermal trauma, skeletal muscle assumes the role of an amino acid reserve where muscle protein breakdown and amino acid release from skeletal muscle serves to buffer plasma amino acid concentrations. Interestingly, it seems like aggressive feeding of the severely burned patient may not necessarily supply amino acids in sufficient abundance to normalize skeletal muscle protein metabolism, suggesting that skeletal muscle becomes an essential store of protein in patients suffering from severe burn trauma. In this article, the effects of burn injury on whole body and skeletal muscle protein metabolism will be discussed in an attempt to distill the current understanding of the impact of this debilitating injury on the redistribution of skeletal muscle protein stores.
Indexed as
Identifiers
23386981PMC3560488W47891013What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.