ArticleScientific reports2013
Neural coding of binary mixtures in a structurally related odorant pair.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The primacy model and the structure of olfactory space.PLoS computational biology · 2024Article
- Article
- What the odor is not: Estimation by elimination.Physical review. E · 2021Article
- A physicochemical model of odor sampling.PLoS computational biology · 2021Article
- Exploring the Characteristics of an Aroma-Blending Mixture by Investigating the Network of Shared Odors and the Molecular Features of Their Related Odorants.Molecules (Basel, Switzerland) · 2020Article
- Competitive binding predicts nonlinear responses of olfactory receptors to complex mixtures.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Odorant mixtures elicit less variable and faster responses than pure odorants.PLoS computational biology · 2018Article
- Antagonism in olfactory receptor neurons and its implications for the perception of odor mixtures.eLife · 2018Article
- Predicting the response of olfactory sensory neurons to odor mixtures from single odor response.Scientific reports · 2016Article
- Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb.Frontiers in computational neuroscience · 2016Article
- From molecule to mind: an integrative perspective on odor intensity.Trends in neurosciences · 2014Review
- The perception of odor objects in everyday life: a review on the processing of odor mixtures.Frontiers in psychology · 2014Review
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2 authors.
Funding
Abstract
The encoding of odorant mixtures by olfactory sensory neurons depends on molecular interactions at peripheral receptors. However, the pharmacological basis of these interactions is not well defined. Both competitive and noncompetitive mechanisms of receptor binding and activation, or suppression, could contribute to coding. We studied this by analyzing responses of olfactory bulb glomeruli evoked by a pair of structurally related odorants, eugenol (EG) and methyl isoeugenol (MIEG). Fluorescence imaging in synaptopHluorin (spH) mice revealed that EG and MIEG evoked highly overlapped glomerular inputs, increasing the likelihood of mixture interactions. Glomerular responses to binary mixtures of EG and MIEG mostly showed hypoadditive interactions at intermediate and high odorant concentrations, with a few near threshold responses showing hyperadditivity. Dose-response profiles were well fitted by a model of two odorants competitively binding and activating a shared receptor linked to a non-linear transduction cascade. We saw no evidence of non-competitive mechanisms.
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