Evidence map›Paper›PMID 23386814›Full record

ArticleFrontiers in integrative neuroscience2013

Issues in localization of brain function: The case of lateralized frontal cortex in cognition, emotion, and psychopathology.

Gregory A Miller, Laura D Crocker, Jeffrey M Spielberg, Zachary P Infantolino, Wendy Heller

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in integrative neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04209023 (The Use of Navigated Transcranial Magnetic Stimulation), which is not on this map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04209023 nasuspendednot on this mapstarted 2023, after this paper: background citation

The Use of Navigated Transcranial Magnetic Stimulation (nTMS) in the Inhibition of Neurofunctional Regions of Interest

TypeinterventionalSponsorNeurological Associates of West Los AngelesRan2023 to 2025Enrolled10ConditionsBrain Tumor, SurgeryArmsTranscranial Magnetic Stimulation
3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Trial
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  5. Review
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  7. Article
  8. Article
  9. Right-lateralized intrinsic brain dynamics predict monitoring abilities.Cognitive, affective & behavioral neuroscience · 2020
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  11. Review
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  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gregory A MillerDepartment of Psychology, University of Delaware Newark, DE, USA ; Department of Psychology, University of Illinois at Urbana-Champaign Champaign, IL, USA ; Zukunftskolleg, University of Konstanz Konstanz, Germany.
Laura D Crocker
Jeffrey M Spielberg
Zachary P Infantolino
Wendy Heller

Funding

Proj 5: Early Development (224-250)P50MH079485 · NIMH · UNIVERSITY OF COLORADO · PI BANICH, MARIE T · 2008 to 2012
$8.7M
MECHANISMS OF ATTENTIONAL BIAS IN PSYCHOPATHOLOGYR01MH061358 · NIMH · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HELLER, WENDY · 2000 to 2009
$2.6M
TRAINING IN COGNITIVE PSYCHOPHYSIOLOGYT32MH019554 · NIMH · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HELLER, WENDY · 1992 to 2012
$2.3M
QUANTITATIVE METHODS FOR EVALUATION AND ASSESSMENTT32MH014257 · NIMH · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI REGENWETTER, MICHEL · 1985 to 2007
$1.9M
Cerebral hemodynamics by simultaneous function MRIR01MH065429 · NIMH · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI WEBB, ANDREW G · 2003 to 2005
$874k
Neurocognitive Mechanisms: Appetitive &Aversive EmotionR21DA014111 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI MILLER, GREGORY ALLEN · 2001 to 2003
$549k
Semantic processing in schizophrenia: Symptoms &memoryF31MH068123 · NIMH · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI FISHER, JOSCELYN ELIZABETH · 2003 to 2005
$100k
NIDA NIH HHS R21 DA014111NIMH NIH HHS F31 MH068123NIMH NIH HHS P50 MH079485NIMH NIH HHS R01 MH061358NIMH NIH HHS R01 MH065429NIMH NIH HHS T32 MH014257NIMH NIH HHS T32 MH019554
6 · The paper itself

Abstract

The appeal of simple, sweeping portraits of large-scale brain mechanisms relevant to psychological phenomena competes with a rich, complex research base. As a prominent example, two views of frontal brain organization have emphasized dichotomous lateralization as a function of either emotional valence (positive/negative) or approach/avoidance motivation. Compelling findings support each. The literature has struggled to choose between them for three decades, without success. Both views are proving untenable as comprehensive models. Evidence of other frontal lateralizations, involving distinctions among dimensions of depression and anxiety, make a dichotomous view even more problematic. Recent evidence indicates that positive valence and approach motivation are associated with different areas in the left-hemisphere. Findings that appear contradictory at the level of frontal lobes as the units of analysis can be accommodated because hemodynamic and electromagnetic neuroimaging studies suggest considerable functional differentiation, in specialization and activation, of subregions of frontal cortex, including their connectivity to each other and to other regions. Such findings contribute to a more nuanced understanding of functional localization that accommodates aspects of multiple theoretical perspectives.

Indexed as

emotionfrontal cortexlateralizationlocalizationmotivation

Identifiers

PMID23386814
PMCPMC3558680

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.