ArticleSocial cognitive and affective neuroscience2014
Disrupted neural processing of emotional faces in psychopathy.
Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Subgenual anterior cingulate cortex in major depression: a systematic review and meta-analysis of MRI studies with patients and healthy controls.Translational psychiatry · 2026Pooled it
- Using physiological biomarkers in forensic psychiatry: a scoping review.Frontiers in psychiatry · 2025Pooled it
- Psychopathy and medial frontal cortex: A systematic review reveals predominantly null relationships.Neuroscience and biobehavioral reviews · 2024Pooled it
- Functional neural correlates of psychopathy: a meta-analysis of MRI data.Translational psychiatry · 2020Pooled it
- A Systematic Literature Review of Neuroimaging of Psychopathic Traits.Frontiers in psychiatry · 2019Pooled it
- Augmentation of frontoparietal gamma-band phase coupling enhances human altruistic behavior.PLoS biology · 2026Article
- The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry.Scientific data · 2025Article
- The association between interoception and psychopathic traits.Frontiers in psychology · 2025Article
- Psychophysiology of facial emotion recognition in psychopathy dimensions and oxytocin's role: A scoping review.PloS one · 2025Article
- The Transdiagnostic Connectome Project: a richly phenotyped open dataset for advancing the study of brain-behavior relationships in psychiatry.medRxiv : the preprint server for health sciences · 2024Article
- Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing.NeuroImage · 2023Article
- Face-Selective Patches in Marmosets Are Involved in Dynamic and Static Facial Expression Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Aberrant motor contagion of emotions in psychopathy and high-functioning autism.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Key challenges in neurocognitive assessment of individuals with antisocial personality disorder and psychopathy.Frontiers in behavioral neuroscience · 2022Article
- An examination of autonomic and facial responses to prototypical facial emotion expressions in psychopathy.PloS one · 2022Article
- [The contribution of forensic neuroscience to psychopathy].L'Encephale · 2020Review
- Left, right, or bilateral amygdala activation? How effects of smoothing and motion correction on ultra-high field, high-resolution functional magnetic resonance imaging (fMRI) data alter inferences.Neuroscience research · 2020Article
- Neural mechanisms of affective matching across faces and scenes.Scientific reports · 2019Article
- An investigation of the relationship between psychopathy and greater gray matter density in lateral prefrontal cortex.Personality neuroscience · 2019Article
- Relationships Between Alexithymia and Psychopathy in Heroin Dependent Individuals.Frontiers in psychology · 2019Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychopaths show a reduced ability to recognize emotion facial expressions, which may disturb the interpersonal relationship development and successful social adaptation. Behavioral hypotheses point toward an association between emotion recognition deficits in psychopathy and amygdala dysfunction. Our prediction was that amygdala dysfunction would combine deficient activation with disturbances in functional connectivity with cortical regions of the face-processing network. Twenty-two psychopaths and 22 control subjects were assessed and functional magnetic resonance maps were generated to identify both brain activation and task-induced functional connectivity using psychophysiological interaction analysis during an emotional face-matching task. Results showed significant amygdala activation in control subjects only, but differences between study groups did not reach statistical significance. In contrast, psychopaths showed significantly increased activation in visual and prefrontal areas, with this latest activation being associated with psychopaths' affective-interpersonal disturbances. Psychophysiological interaction analyses revealed a reciprocal reduction in functional connectivity between the left amygdala and visual and prefrontal cortices. Our results suggest that emotional stimulation may evoke a relevant cortical response in psychopaths, but a disruption in the processing of emotional faces exists involving the reciprocal functional interaction between the amygdala and neocortex, consistent with the notion of a failure to integrate emotion into cognition in psychopathic individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.