Evidence map›Paper›PMID 23386641›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2013

Effects of vitamin D supplementation in older African American women.

J Christopher Gallagher, Munro Peacock, Vinod Yalamanchili, Lynette M Smith

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

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  4. Dose ranging effects of vitamin D3 on the geriatric depression score: A clinical trial.The Journal of steroid biochemistry and molecular biology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

J Christopher GallagherBone Metabolism Unit, Creighton University School of Medicine, 601 North 30th Street, Suite 6718, Omaha, Nebraska 68131, USA. jcg@creighton.edu
Munro Peacock
Vinod Yalamanchili
Lynette M Smith
Creighton University · USIndiana University School of MedicineUniversity of Nebraska Medical Center · US

Funding

Determination of RDA for Vitamin D in Caucasian and African American WomenR01AG028168 · NIA · CREIGHTON UNIVERSITY · PI GALLAGHER, JOHN CHRISTOPHER · 2006 to 2009
$1.9M
NIA NIH HHS AG28168NIA NIH HHS R01 AG028168
6 · The paper itself

Abstract

contextSerum 25-hydroxyvitamin D (25OHD) is lower in women with darker skin color. Is it due to lower skin production, lower absorption, or different metabolism of vitamin D?

objectivesThe objective of the study was to measure the effect of vitamin D3 on serum 25OHD and serum PTH in older African American women with vitamin D insufficiency and the serum 25OHD 20 ng/mL or less (<50 nmol/L). The results can be used to estimate the Recommended Dietary Allowance (RDA). DESIGN AND

settingThis was a randomized, double-blind placebo trial at Creighton University Medical Center and Indiana University Medical Center.

participantsParticipants were 110 healthy older African American women.

interventionsThe intervention consisted of participants randomly assigned to placebo, vitamin D3 400, 800, 1600, 2400, 3200, 4000, or 4800 IU daily; calcium supplements were given to maintain total calcium intake of 1200-1400 mg/d. MAIN OUTCOME MEASUREMENTS: Change in serum 25OHD and serum PTH levels at 12 months was measured.

resultsMean baseline serum 25OHD was 13 ng/mL (33 nmol/L). On 4800 IU, serum 25OHD averaged 50 ng/mL (125 nmol/L) compared with 47 ng/mL (117 nmol/L) in Caucasian women. Serum PTH at 12 months decreased significantly (P = .008) when related to serum 25OHD but not dose. Hypercalcemia occurred in 7% and hypercalciuria in 15%. Events were unrelated to vitamin D dose.

conclusionVitamin D3 800 IU increased serum 25OHD greater than 20 ng/mL (>50 nmol/L) in 97.5% of the African American women just as it did in the Caucasian women, and therefore, the RDA is the same for both groups. Because absorption and metabolism of oral vitamin D absorption is similar in both groups, lower levels of serum 25OHD in African Americans must be due to lower production of vitamin D in skin.

Indexed as

Black or African AmericanAgedAged, 80 and overAgingCalcium, DietaryCholecalciferolDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMiddle AgedParathyroid HormonePlacebosProspective StudiesVitamin DVitamin D Deficiency25-hydroxyvitamin DCalcium, DietaryCholecalciferolParathyroid HormonePlacebosVitamin DVitamins

Identifiers

PMID23386641
PMCPMC3590472
OpenAlexW2117129062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.