Evidence map›Paper›PMID 23386630›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2013

Prevalent and incident hepatitis C virus infection among HIV-infected men who have sex with men engaged in primary care in a Boston community health center.

Shikha Garg, Lynn E Taylor, Chris Grasso, Kenneth H Mayer

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
  2. Pooled it
  3. Pooled it
  4. Sexually transmitted diseases treatment guidelines, 2015.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2015
    Guideline
  5. Guideline
  6. Telaprevir in the treatment of acute hepatitis C virus infection in HIV-infected men.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014
    Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. SNP rs688 within the low-density lipoprotein receptor (LDL-R) gene associates with HCV susceptibility.Liver international : official journal of the International Association for the Study of the Liver · 2019
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors.

Shikha GargTufts Medical Center, Boston, MA, USA. shikhagarg75@yahoo.com
Lynn E Taylor
Chris Grasso
Kenneth H Mayer

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI JOSEPH W HOGAN · 1998 to 2026
$51.7M
NEMCH CLINICAL RESEARCH ON AIDS TRAINING GRANTT32AI007438 · NIAID · TUFTS MEDICAL CENTER · PI WANKE, CHRISTINE A · 1992 to 2012
$2.5M
Buprenorphine as a Bridge to HCV Treatment for HIV/HCV Coinfected Opioid UsersK23DA020383 · NIDA · MIRIAM HOSPITAL · PI TAYLOR, LYNN ERICA · 2008 to 2012
$882k
NIAID NIH HHS 5T32AI007438-17NIAID NIH HHS P30 AI042853NIAID NIH HHS P30AI042853NIAID NIH HHS T32 AI007438NIDA NIH HHS K23 DA020383NIDA NIH HHS K23DA020383
6 · The paper itself

Abstract

backgroundSexually transmitted hepatitis C virus (HCV) infection is an emerging epidemic among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). HCV may be underrecognized in this population, historically thought to be at low risk.

methodsWe determined the prevalence and incidence of HCV among HIV-infected men at Fenway Health between 1997 and 2009. We describe characteristics associated with HCV.

resultsOf 1171 HIV-infected men, of whom 96% identify as MSM, 1068 (91%) were screened for HCV and 64 (6%) had a positive HCV antibody (Ab) result at initial screening. Among the 995 men whose initial HCV Ab result was negative, 62% received no further HCV Ab testing. Among the 377 men who had ≥1 additional HCV Ab test, 23 (6%) seroconverted over 1408 person-years, for an annualized incidence of 1.63 per 100 person-years (95% confidence interval, .97-2.30). Among the 87 HIV-infected MSM diagnosed with prevalent or incident HCV, 33% reported history of injection drug use, 46% noninjection drug use (NIDU), and 70% sexually transmitted infections (STIs). Sixty-four (74%) of HCV-infected MSM developed chronic HCV; 22 (34%) initiated HCV treatment and 13 (59%) of treated persons achieved a sustained virologic response (SVR).

conclusionsPrevalent and incident HCV, primarily acquired through nonparenteral means, was common in this HIV-infected population despite engagement in care. STIs and NIDU were common among HIV/HCV-coinfected MSM. SVR rates were high among those who underwent HCV treatment. All sexually active and/or substance-using HIV-infected MSM should receive routine and repeated HCV screening to allow for early diagnosis and treatment of HCV.

Indexed as

AdolescentAdultAgedBostonCommunity Health CentersHepatitis CHIV InfectionsHomosexuality, MaleHumansIncidenceMaleMass ScreeningMiddle AgedPrevalenceRetrospective StudiesStatistics, Nonparametric

Identifiers

PMID23386630
PMCPMC3634307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.