Evidence map›Paper›PMID 23386608›Full record

ArticleThe Journal of biological chemistry2013

Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa.

Novruz B Ahmedli, Yekaterina Gribanova, Collins C Njoku, Akash Naidu, Alejandra Young, Emmanuel Mendoza, Clyde K Yamashita, Riza Köksal Özgül, Jerry E Johnson, Donald A Fox and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Rhomboids, signalling and cell biology.Biochemical Society transactions · 2016
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Novruz B AhmedliJules Stein Eye Institute, UCLA, Los Angeles, California 90095. Electronic address: akhmedov@jsei.ucla.edu.
Yekaterina GribanovaJules Stein Eye Institute, UCLA, Los Angeles, California 90095.
Collins C NjokuJules Stein Eye Institute, UCLA, Los Angeles, California 90095.
Akash NaiduJules Stein Eye Institute, UCLA, Los Angeles, California 90095.
Alejandra YoungJules Stein Eye Institute, UCLA, Los Angeles, California 90095.
Emmanuel MendozaJules Stein Eye Institute, UCLA, Los Angeles, California 90095.
Clyde K YamashitaJules Stein Eye Institute, UCLA, Los Angeles, California 90095.
Riza Köksal ÖzgülDepartment of Molecular Biology, Hacettepe University, 06230 Beytepe-Ankara, Turkey.
Jerry E JohnsonDepartment of Natural Sciences, University of Houston-Downtown, Houston, Texas 77002.
Donald A FoxCollege of Optometry, University of Houston, Houston, Texas 77004; Department of Biology and Biochemistry, University of Houston, Houston, Texas 77004; Department of Pharmacology and Pharmaceutical Sciences, University of Houston, Houston, Texas 77004.
Debora B FarberJules Stein Eye Institute, UCLA, Los Angeles, California 90095; Molecular Biology Institute, UCLA, Los Angeles, California 90095; Brain Research Institute, UCLA, Los Angeles, California 90095.
Hacettepe University · TRUniversity of Houston · USUniversity of Houston - Downtown · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI VALLABH E DAS · 1988 to 2026
$16.4M
MOLECULAR MECHANISMS IN RETINAL DEGENERATIONSR01EY008285 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FARBER, DEBORA B · 1989 to 2011
$4.0M
Training Program with Universitiy of HoustonT32EY007024 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MASSEY, STEPHEN C · 1987 to 2016
$1.8M
Low-Level Prenatal Lead Exposure and Retinal ToxicityR01ES012482 · NIEHS · UNIVERSITY OF HOUSTON · PI FOX, DONALD A · 2003 to 2009
$1.7M
NEI NIH HHS P30 EY000331NEI NIH HHS P30 EY007551NEI NIH HHS P30 EY07551NEI NIH HHS R01 EY008285NEI NIH HHS R01 EY08285NEI NIH HHS T32 EY007024NEI NIH HHS T32 EY07024NIEHS NIH HHS R01 ES012482
6 · The paper itself

Abstract

The novel rhomboid-like protein RHBDD2 is distantly related to rhomboid proteins, a group of highly specialized membrane-bound proteases that catalyze regulated intramembrane proteolysis. In retina, RHBDD2 is expressed from embryonic stages to adulthood, and its levels show age-dependent changes. RHBDD2 is distinctly abundant in the perinuclear region of cells, and it localizes to their Golgi. A glycine zipper motif present in one of the transmembrane domains of RHBDD2 is important for its packing into the Golgi membranes. Its deletion causes dislodgment of RHBDD2 from the Golgi. A specific antibody against RHBDD2 recognizes two forms of the protein, one with low (39 kDa; RHBDD2(L)) and the other with high (117 kDa; RHBDD2H) molecular masses in mouse retinal extracts. RHBDD2(L) seems to be ubiquitously expressed in all retinal cells. In contrast, RHBDD2H seems to be present only in the outer segments of cone photoreceptors and may correspond to a homotrimer of RHBDD2(L). This protein consistently co-localizes with S- and M-types of cone opsins. We identified a homozygous mutation in the human RHBDD2 gene, R85H, that co-segregates with disease in affected members of a family with autosomal recessive retinitis pigmentosa. Our findings suggest that the RHBDD2 protein plays important roles in the development and normal function of the retina.

Indexed as

Amino Acid MotifsAmino Acid SequenceAnimalsCell MembraneEndopeptidasesFemaleGene Expression RegulationGene Expression Regulation, DevelopmentalGlycineGolgi ApparatusHEK293 CellsHomozygoteHumansImmunohistochemistryIn Situ HybridizationMembrane ProteinsEndopeptidasesGlycineMembrane ProteinsNeoplasm ProteinsOpsinsRHBDD2 protein, humanRHBDD2 protein, mouse

Identifiers

PMID23386608
PMCPMC3617276
OpenAlexW2005058366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.