ArticleThe Journal of comparative neurology2013
Axon diversity of lamina I local-circuit neurons in the lumbar spinal cord.
Article in The Journal of comparative neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Article
- Model-based analysis of subthreshold mechanisms of spinal cord stimulation for pain.Journal of neural engineering · 2023Article
- Contralateral Afferent Input to Lumbar Lamina I Neurons as a Neural Substrate for Mirror-Image Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Quantitative spatial analysis reveals that the local axons of lamina I projection neurons and interneurons exhibit distributions that predict distinct roles in spinal sensory processing.The Journal of comparative neurology · 2022Article
- Presynaptic Interactions between Trigeminal and Cervical Nociceptive Afferents Supplying Upper Cervical Lamina I Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- History of Spinal Cord "Pain" Pathways Including the Pathways Not Taken.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Real-World Outcomes Using a Spinal Cord Stimulation Device Capable of Combination Therapy for Chronic Pain: A European, Multicenter Experience.Journal of clinical medicine · 2021Article
- Improved Pain Control with Combination Spinal Cord Stimulator Therapy Utilizing Sub-perception and Traditional Paresthesia Based Waveforms: A Pilot Study.Anesthesiology and pain medicine · 2021Article
- Presynaptic Inhibition of Pain and Touch in the Spinal Cord: From Receptors to Circuits.International journal of molecular sciences · 2021Review
- Projection Neuron Axon Collaterals in the Dorsal Horn: Placing a New Player in Spinal Cord Pain Processing.Frontiers in physiology · 2020Review
- Spatial organization of activity evoked by focal stimulation within the rat spinal dorsal horn as visualized by voltage-sensitive dye imaging in the slice.Journal of neurophysiology · 2019Article
- Functional Characterization of Lamina X Neurons inFrontiers in cellular neuroscience · 2017Article
- Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn.Molecular pain · 2017Review
- Na+ current in presynaptic terminals of the crayfish opener cannot initiate action potentials.Journal of neurophysiology · 2016Article
- Article
- Pacemaker Neurons and the Development of Nociception.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses.The Journal of physiology · 2014Article
- Versatile morphometric analysis and visualization of the three-dimensional structure of neurons.Neuroinformatics · 2013Article
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Authors and funding
8 authors.
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Abstract
Spinal lamina I is a key area for relaying and integrating information from nociceptive primary afferents with various other sources of inputs. Although lamina I projection neurons have been intensively studied, much less attention has been given to local-circuit neurons (LCNs), which form the majority of the lamina I neuronal population. In this work the infrared light-emitting diode oblique illumination technique was used to visualize and label LCNs, allowing reconstruction and analysis of their dendritic and extensive axonal trees. We show that the majority of lamina I neurons with locally branching axons fall into the multipolar (with ventrally protruding dendrites) and flattened (dendrites limited to lamina I) somatodendritic categories. Analysis of their axons revealed that the initial myelinated part gives rise to several unmyelinated small-diameter branches that have a high number of densely packed, large varicosities and an extensive rostrocaudal (two or three segments), mediolateral, and dorsoventral (reaching laminae III-IV) distribution. The extent of the axon and the occasional presence of long, solitary branches suggest that LCNs may also form short and long propriospinal connections. We also found that the distribution of axon varicosities and terminal field locations show substantial heterogeneity and that a substantial portion of LCNs is inhibitory. Our observations indicate that LCNs of lamina I form intersegmental as well as interlaminar connections and may govern large numbers of neurons, providing anatomical substrate for rostrocaudal "processing units" in the dorsal horn.
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