Evidence map›Paper›PMID 23386289›Full record

ArticleJournal of clinical immunology2013

Diabetes, renal and cardiovascular disease in p47 phox-/- chronic granulomatous disease.

Jennifer W Leiding, Beatriz E Marciano, Christa S Zerbe, Suk See Deravin, Harry L Malech, Steven M Holland

Abstract read
In one paragraph

Article in Journal of clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. p47Journal of clinical immunology · 2018
    Review
  5. Article
  6. NADPH Oxidase Deficiency: A Multisystem Approach.Oxidative medicine and cellular longevity · 2017
    Review
  7. Primary immune deficiencies with defects in neutrophil function.Hematology. American Society of Hematology. Education Program · 2016
    Review
  8. Chronic Granulomatous Disease.Indian journal of pediatrics · 2016
    Review
  9. Review
  10. Common severe infections in chronic granulomatous disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jennifer W LeidingLaboratories of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1684, USA.
Beatriz E Marciano
Christa S Zerbe
Suk See Deravin
Harry L Malech
Steven M Holland
National Institutes of Health · USNational Institute of Allergy and Infectious Diseases · USUniversity of South Florida · US

Funding

Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
Gene Therapy Basic Research to Treat Inherited Primary Immune DeficienciesZIAAI000644 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MALECH, HARRY L · 2009 to 2025
$12.1M
Development and Clinical Application of Gene and Cell therapies for Patients with Immune DeficienciesZIAAI000645 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DE RAVIN, SUK SEE · 2009 to 2025
$10.1M
TRANSGENIC ANIMAL MODELS OF HUMAN IMMUNE DEFECTSZ01AI000646 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI HOLLAND, STEVEN M · 1992 to 2008
$2.4M
Intramural NIH HHS Z01 AI000646
6 · The paper itself

Abstract

Chronic granulomatous disease is a rare immunodeficiency due to defects in the phagocyte NADPH oxidase. The X-linked form (gp91 (phox) deficiency) accounts for about 70 % of cases; autosomal recessive p47 (phox) deficiency accounts for about 25 % of cases. We identified a 10 % incidence of diabetes in p47 (phox) deficient CGD, but none in X-linked CGD. Renal and cardiovascular diseases were also higher in p47 (phox) deficiency. p47 (phox) deficient CGD has non-infectious morbidities distinct from those in X-linked CGD.

Indexed as

AdolescentAdultCardiovascular DiseasesComorbidityDiabetes MellitusFemaleGranulomatous Disease, ChronicHumansMaleMembrane GlycoproteinsMiddle AgedNADPH Oxidase 2NADPH OxidasesPhagocytesRenal Insufficiency, ChronicYoung AdultCYBB protein, humanMembrane GlycoproteinsNADPH Oxidase 2NADPH Oxidasesneutrophil cytosolic factor 1

Identifiers

PMID23386289
PMCPMC4082696
OpenAlexW1985655613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.