ArticleClinical research in cardiology : official journal of the German Cardiac Society2013
Autonomic involvement in idiopathic premature ventricular contractions.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Revisiting exercise-induced premature ventricular complexes as a prognostic factor for mortality in asymptomatic patients: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Dependence of premature ventricular complexes on heart rate-it's not that simple.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Development of an electrocardiographic prediction model for outflow tract idiopathic premature ventricular contraction with decreased left ventricular ejection fraction.European journal of medical research · 2025Article
- Sex-Specific Analysis of the Relationship Between Ventricular Premature Contractions Frequency Distribution and Heart Rate: A Cross-Sectional Study in Chinese Adults.International journal of general medicine · 2025Article
- Mechanisms and Risk Factors for Premature Ventricular Contraction Induced Cardiomyopathy.Reviews in cardiovascular medicine · 2023Review
- Relationship between epicardial adipose tissue measured by computed tomography and premature ventricular complexes originating from different sites.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Article
- The role of pre-participation cardiac evaluation in the management of an athlete with premature ventricular contraction-induced cardiomyopathy: a case report.European heart journal. Case reports · 2022Article
- Article
- Skin sympathetic nerve activity in patients with obstructive sleep apnea.Heart rhythm · 2020Article
- Utility of Circadian Variability Patterns in Differentiating Origins of Premature Ventricular Complexes.Journal of interventional cardiology · 2020Article
- Premature ventricular contractions activate vagal afferents and alter autonomic tone: implications for premature ventricular contraction-induced cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2019Article
- Autonomic influences related to frequent ventricular premature beats in patients without structural heart disease.Medicine · 2018Observational
- Sympathetic Activity Index Should Be Kept in Mind When Assessing Autonomic Tonus.Korean circulation journal · 2016Article
- Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine.Frontiers in physiology · 2015Article
- Symptomatic arrhythmias due to syringomyelia-induced severe autonomic dysfunction.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate autonomic involvement in different types of idiopathic premature ventricular contractions (PVCs) grouped by heart rate (HR) dependency.
methodsOne hundred and sixty PVC patients and 31 controls were enrolled. Holter ECG was used to evaluate PVC occurrence, and spectral analysis of heart rate variability (HRV) was calculated to represent cardiac autonomic control. PVCs were divided into fast rate-dependent (F-PVC), slow rate-dependent (S-PVC), and HR-independent PVC (I-PVC) based on the relationship between hourly PVC density and hourly HR. HRV among different types of PVCs were compared, and the association between PVC density with HR and HRV were analyzed. Furthermore, autonomic changes assessed by consecutive 5-min HRV in 30 min before PVC episodes were investigated.
resultsIn 160 subjects, there were 73 F-PVC, 56 S-PVC, and 31 I-PVC. Hourly PVC density was positively associated with sympathetic indice (LF/HF) and negatively related to vagal indices (HF and HFnu) in F-PVC, and this trend was reversed in S-PVC. During 30 min before PVC onset, RR interval and HFnu decreased significantly with LF/HF showing an increasing trend in F-PVC, while in S-PVC both RR interval and HF increased significantly. It was noted that those changes were most evident during the last 5 min before PVC onset. In addition, PVC density in F-PVC was significantly decreased by β-blocker treatment.
conclusionsHR dependency reflected autonomic modulation of idiopathic PVCs. F-PVC and S-PVC might be facilitated by sympathetic activation and vagal activation, respectively. HR dependency and the related autonomic mechanisms should be considered when treating idiopathic PVCs.
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