ArticleJournal of molecular neuroscience : MN2013
Increased expression of small heat shock protein αB-crystallin after intracerebral hemorrhage in adult rats.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Metformin Attenuates Neurological Deficit after Intracerebral Hemorrhage by Inhibiting Apoptosis, Oxidative Stress and Neuroinflammation in Rats.Neurochemical research · 2017Article
- Up-regulation of Vps4A promotes neuronal apoptosis after intracerebral hemorrhage in adult rats.Metabolic brain disease · 2017Article
- OTUB1 attenuates neuronal apoptosis after intracerebral hemorrhage.Molecular and cellular biochemistry · 2016Article
- A New Role Discovered for IGTP: The Protective Effect of IGTP in ICH-Induced Neuronal Apoptosis.Cellular and molecular neurobiology · 2016Article
- Crystallins and neuroinflammation: The glial side of the story.Biochimica et biophysica acta · 2016Article
- Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter.Acta neuropathologica communications · 2015Article
- Up-Regulation of KPNB1 Involves in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats.Neurochemical research · 2015Article
- Protective Effect of Pyrroloquinoline Quinone (PQQ) in Rat Model of Intracerebral Hemorrhage.Cellular and molecular neurobiology · 2015Article
- Increased Expression of Mitochondrial Inner-Membrane Protein Mpv17 After Intracerebral Hemorrhage in Adult Rats.Neurochemical research · 2015Article
- Up-regulation of VCAM1 Relates to Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.Neurochemical research · 2015Article
- CDK5 contributes to neuronal apoptosis via promoting MEF2D phosphorylation in rat model of intracerebral hemorrhage.Journal of molecular neuroscience : MN · 2015Article
- Up-regulation of Glis2 involves in neuronal apoptosis after intracerebral hemorrhage in adult rats.Cellular and molecular neurobiology · 2015Article
- BTEB2 prevents neuronal apoptosis via promoting bad phosphorylation in rat intracerebral hemorrhage model.Journal of molecular neuroscience : MN · 2015Article
- Upregulation of EHD2 after intracerebral hemorrhage in adult rats.Journal of molecular neuroscience : MN · 2014Article
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11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
αB-crystallin (αBC) is involved in diverse cellular activities. Previous studies demonstrated that αBC had anti-apoptotic and proliferation-promoting effects in multiple diseases. Here, we explored the αBC's roles in the pathophysiology of intracerebral hemorrhage (ICH). An ICH rat model was established and assessed by behavioral tests. Using Western blot and immunohistochemistry, significant up-regulation of αBC was found in neurons and astrocytes in brain areas surrounding the hematoma following ICH. Increase of αBC expression was found to be accompanied by the increased expression of proliferating cell nuclear antigen (PCNA), p53, Bax, and active-caspase-3. αBC was co-localized with PCNA in astrocytes or active-caspase-3 in neurons, suggesting its role in astrocyte proliferation and neuronal apoptosis. Our in vitro study, using αBC RNA interference in PC12 cells, indicated that αBC might exert its anti-apoptotic function in neuronal apoptosis. Thus, αBC may play a role in protecting the brain from secondary damage following ICH.
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