ArticlePharmaceutical research2013
Microfluidic synthesis of PEG- and folate-conjugated liposomes for one-step formation of targeted stealth nanocarriers.
Article in Pharmaceutical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cryopreservation technology for improving the stability of liposomes and its precise drug monitoring in clinical drug research.Drug delivery · 2026Article
- Microfluidic preparation of size- and lamellarity-controlled liposomes using a static mixer and the advantage of a multilamellar structure in biosensing applications.Frontiers in bioengineering and biotechnology · 2025Article
- Leveraging Numerical Simulation Technology to Advance Drug Preparation: A Comprehensive Review of Application Scenarios and Cases.Pharmaceutics · 2024Review
- Neuroprotective Effect of Curcumin-Loaded RGD Peptide-PEGylated Nanoliposomes.Pharmaceutics · 2023Article
- Microfluidic approaches for producing lipid-based nanoparticles for drug delivery applications.Biophysics reviews · 2023Review
- Microfluidic Generation of Near-Infrared Photothermal Vitexin/ICG Liposome with Amplified Photodynamic Therapy.AAPS PharmSciTech · 2023Article
- An emerging era in manufacturing of drug delivery systems: Nanofabrication techniques.Heliyon · 2023Review
- Microfluidic vortex focusing for high throughput synthesis of size-tunable liposomes.Nature communications · 2022Article
- Microfluidic Manufacture of Lipid-Based Nanomedicines.Pharmaceutics · 2022Review
- Microfluidic Applications in Drug Development: Fabrication of Drug Carriers and Drug Toxicity Screening.Micromachines · 2022Review
- Formulation Strategies for Folate-Targeted Liposomes and Their Biomedical Applications.Pharmaceutics · 2019Review
- Review
- Continuous-Flow Production of Injectable Liposomes via a Microfluidic Approach.Materials (Basel, Switzerland) · 2017Article
- Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery.Journal of drug delivery · 2017Article
- Liposome production by microfluidics: potential and limiting factors.Scientific reports · 2016Review
- Microfluidic remote loading for rapid single-step liposomal drug preparation.Lab on a chip · 2014Article
- Liposomal delivery and polyethylene glycol-liposomal oxaliplatin for the treatment of colorectal cancer (Review).Biomedical reports · 2014Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeA microfluidic hydrodynamic flow focusing technique enabling the formation of small and nearly monodisperse liposomes is investigated for continuous-flow synthesis of poly(ethylene glycol) (PEG)-modified and PEG-folate-functionalized liposomes for targeted drug delivery.
methodsControlled laminar flow in thermoplastic microfluidic devices facilitated liposome self-assembly from initial lipid compositions including lipid/cholesterol mixtures containing PEG-lipid and folate-PEG-lipid conjugates. Relationships among flow conditions, lipid composition, and liposome size were evaluated; their impact on PEG and folate incorporation were determined through a combination of UV-vis absorbance measurements and characterization of liposome zeta potential.
resultsPEG and folate were successfully incorporated into microfluidic-synthesized liposomes over the full range of liposome sizes studied. Efficiency of PEG-lipid incorporation was inversely correlated with liposome diameter. Folate-lipid was effectively integrated into liposomes at various flow conditions.
conclusionsLiposomes incorporating relatively large PEG-modified and folate-PEG-modified lipids were successfully synthesized using the microfluidic flow focusing platform, providing a simple, low cost, rapid method for preparing functionalized liposomes. Relationships between preparation conditions and PEG or folate-PEG functionalization have been elucidated, providing insight into the process and defining paths for optimization of the microfluidic method toward the formation of functionalized liposomes for pharmaceutical applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.