Trial reportInvestigative ophthalmology & visual science2013
Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis.
Trial report in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00324168 (Steroids for Corneal Ulcers Trial), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Steroids for Corneal Ulcers Trial
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Topical corticosteroids as adjunctive therapy for bacterial keratitis.The Cochrane database of systematic reviews · 2014Pooled it
- The Utility of Repeat Culture in Fungal Corneal Ulcer Management: A Secondary Analysis of the MUTT-I Randomized Clinical Trial.American journal of ophthalmology · 2017Trial
- Microbiological profiles of infectious corneal ulcers in Derbyshire and North Nottinghamshire-a 10-year analysis.International ophthalmology · 2025Article
- Bacterial and Fungal Keratitis in a Tertiary Care Hospital from Romania.Microorganisms · 2024Article
- Infectious keratitis in Western New York: a 10-year review of patient demographics, clinical management, and treatment failure.Frontiers in ophthalmology · 2024Article
- Staphylococcal Enterotoxins Promote Virulence in Bacterial Keratitis.Investigative ophthalmology & visual science · 2023Article
- Simultaneous control of infection and inflammation with keratin-derived antibacterial peptides targeting TLRs and co-receptors.Science translational medicine · 2023Article
- Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology.Frontiers in medicine · 2021Article
- Treatment-Resistant Bacterial Keratitis: Challenges and Solutions.Clinical ophthalmology (Auckland, N.Z.) · 2020Review
- Rho Kinase Type 1 (ROCK1) Promotes Lipopolysaccharide-induced Inflammation in Corneal Epithelial Cells by Activating Toll-Like Receptor 4 (TLR4)-Mediated Signaling.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Update on the Management of Infectious Keratitis.Ophthalmology · 2017Review
- Corneal infection in Shandong peninsula of China: a 10-year retrospective study on 578 cases.International journal of ophthalmology · 2016Article
- Role of steroids in the treatment of bacterial keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- Pattern recognition receptors in microbial keratitis.Eye (London, England) · 2015Review
- Anti-inflammatory effect of emodin on lipopolysaccharide-induced keratitis in Wistar rats.International journal of clinical and experimental medicine · 2015Article
- Emodin ameliorates lipopolysaccharides-induced corneal inflammation in rats.International journal of ophthalmology · 2015Article
- Topical Corticosteroids in the Management of Bacterial Keratitis.Current ophthalmology reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeBacterial keratitis is a sight-threatening infection of the cornea that is one of the leading causes of blindness globally. In this report, we analyze the role of moxifloxacin susceptibility in the relationship between causative organisms and clinical outcome in bacteria keratitis.
methodsA mediation analysis is used to assess the role of moxifloxacin susceptibility in the relationship between causative organisms and clinical outcome in bacterial keratitis using data collected in a randomized, controlled trial.
resultsIn the Steroids for Corneal Ulcers Trial (SCUT), 500 corneal infections were treated with topical moxifloxacin. The outcome of 3-week best spectacle-corrected visual acuity was significantly associated with an organism (Streptococcus pneumoniae, Pseudomonas aeruginosa, etc., P = 0.008). An indirect effects mediation model suggests that MIC accounted for approximately 13% (95% confidence interval, 3%-24%, P = 0.015) of the effect of the organism on 3-week visual acuity.
conclusionsMoxifloxacin mediates the relationship between causative organisms and clinical outcome in bacterial keratitis, and is likely on the causal pathway between the organism and outcome. (ClinicalTrials.gov number, NCT00324168.).
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.