ReviewContinuum (Minneapolis, Minn.)2013
Circadian rhythm abnormalities.
Review in Continuum (Minneapolis, Minn.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 196 citations in OpenAlex.
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Recent Advances in Sleep and Circadian Characteristics in Eating Disorders: A Systematic Review of the Last Five Years (2020-2025).Nature and science of sleep · 2026Review
- Exploring Sleep Challenges and Interventions in Children with a Vision Impairment: A Scoping Review.Children (Basel, Switzerland) · 2025Review
- Different Protocols of Circadian Rhythm Disruptions Differentially Affect Locomotor Activity, and Anxiety- and Compulsive-Like Behaviors in Male vs. Female Wistar Rats along with the Significant Involvement of GSK-3β in Females.Molecular neurobiology · 2025Article
- Casein kinase 1 family member CSNK1E can regulate proliferation and migration in hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2025Article
- The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs.Molecules (Basel, Switzerland) · 2025Review
- Cancer Patients Circadian Rhythm Assessment Based on Morningness-Eveningness Preference: A Cross-Sectional Study.Health science reports · 2025Article
- The impact of postoperative pain interventions on circadian rhythm disruptions: mechanisms and clinical implications.Frontiers in neuroscience · 2025Review
- Non-Hereditary Obesity Type Networks and New Drug Targets: An In Silico Approach.International journal of molecular sciences · 2024Article
- Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS).The Prostate · 2024Review
- The Role of Circadian Rhythms and Sleep in Anorexia Nervosa.JAMA network open · 2024Article
- Quality of Life and Sexual Satisfaction in the Early Period of Motherhood-A Cross-Sectional Preliminary Study.Journal of clinical medicine · 2023Article
- The association of circadian parameters and the clustering of fatigue, depression, and sleep problems in breast cancer survivors: a latent class analysis.Journal of cancer survivorship : research and practice · 2023Article
- Seasonal variation and sleep patterns in a hot climate Arab Region.Sleep & breathing = Schlaf & Atmung · 2023Article
- Time of day of exercise does not affect the beneficial effect of exercise on bone structure in older female rats.Frontiers in physiology · 2023Article
- Early chronotype with metabolic syndrome favours resting and exercise fat oxidation in relation to insulin-stimulated non-oxidative glucose disposal.Experimental physiology · 2022Article
- Pediatric sleep and pain: etiologies, consequences, and clinical considerations.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Review
- Insulin Sensitivity and Metabolic Flexibility Parallel Plasma TCA Levels in Early Chronotype With Metabolic Syndrome.The Journal of clinical endocrinology and metabolism · 2022Article
- Association between sleep status and lower urinary tract symptoms among men aged 40 or older in Zhengzhou.Sleep and biological rhythms · 2022Article
- Relationships between the changes in sleep patterns and sleep quality among Chinese people during the 2019 coronavirus disease outbreak.Sleep medicine · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 4 countries.
Funding
Abstract
purposeThis article reviews the recent advances in understanding of the fundamental properties of circadian rhythms and discusses the clinical features, diagnosis, and treatment of circadian rhythm sleep disorders (CRSDs). RECENT
findingsRecent evidence strongly points to the ubiquitous influence of circadian timing in nearly all physiologic functions. Thus, in addition to the prominent sleep and wake disturbances, circadian rhythm disorders are associated with cognitive impairment, mood disturbances, and increased risk of cardiometabolic disorders. The recent availability of biomarkers of circadian timing in clinical practice has improved our ability to identify and treat these CRSDs. SUMMARY: Circadian rhythms are endogenous rhythms with a periodicity of approximately 24 hours. These rhythms are synchronized to the physical environment by social and work schedules by various photic and nonphotic stimuli. CRSDs result from a misalignment between the timing of the circadian rhythm and the external environment (eg, jet lag and shift work) or a dysfunction of the circadian clock or its afferent and efferent pathways (eg, delayed sleep-phase, advanced sleep-phase, non-24-hour, and irregular sleep-wake rhythm disorders). The most common symptoms of these disorders are difficulties with sleep onset and/or sleep maintenance and excessive sleepiness that are associated with impaired social and occupational functioning. Effective treatment for most of the CRSDs requires a multimodal approach to accelerate circadian realignment with timed exposure to light, avoidance of bright light at inappropriate times, and adherence to scheduled sleep and wake times. In addition, pharmacologic agents are recommended for some of the CRSDs. For delayed sleep-phase, non-24-hour, and shift work disorders, timed low-dose melatonin can help advance or entrain circadian rhythms; and for shift work disorder, wake-enhancing agents such as caffeine, modafinil, and armodafinil are options for the management of excessive sleepiness.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.