ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
Memory of conditioned taste aversion is erased by inhibition of PI3K in the insular cortex.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Anterior insular cortex regulates depression-like and ASD-like behaviors via the differential contribution of two subsets of microglia.Molecular psychiatry · 2026Article
- HMBA ameliorates obesity by MYH9- and ACTG1-dependent regulation of hypothalamic neuropeptides.EMBO molecular medicine · 2023Article
- Selective TAAR1 agonists induce conditioned taste aversion.Psychopharmacology · 2022Article
- Differential Recruitment of the Infralimbic Cortex in Recent and Remote Retrieval and Extinction of Aversive Memory in Post-Weanling Rats.The international journal of neuropsychopharmacology · 2022Article
- Infralimbic BDNF signaling is necessary for the beneficial effects of extinction on set shifting in stressed rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Taste Processing: Insights from Animal Models.Molecules (Basel, Switzerland) · 2020Review
- Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma?International journal of molecular sciences · 2020Review
- Response of the Tail of the Ventral Tegmental Area to Aversive Stimuli.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- The Insula and Taste Learning.Frontiers in molecular neuroscience · 2017Review
- PI3-kinase cascade has a differential role in acquisition and extinction of conditioned fear memory in juvenile and adult rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Dissociation of the Role of Infralimbic Cortex in Learning and Consolidation of Extinction of Recent and Remote Aversion Memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
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3 authors.
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Abstract
The conditioned taste aversion (CTA) paradigm, in which association between a novel taste and visceral malaise is formed, gives a unique experimental setting to examine the mechanisms underlying memory acquisition and extinction processes. AKT is a main kinase of the phosphoinositide 3-kinase cascade (PI3K) and has been implicated in long-term memory. We have recently reported that blockade of PI3K in the basolateral amygdala (BLA) before retrieval of fear memory was associated with long-term reduction in fear responses, suggesting a possible role of PI3K inhibition in fear erasure. In this study, we aimed to elucidate whether PI3K has a similar role in the insular cortex (IC), which has a crucial role in CTA acquisition, consolidation, maintenance, and extinction. To that end, we (1) monitored AKT phosphorylation in the IC following CTA acquisition and extinction and (2) inhibited PI3K by local microinjection of the PI3K inhibitor LY294002 at different stages of CTA acquisition and extinction. Our results show that while AKT phosphorylation is increased following CTA learning, it is decreased following CTA extinction. Inhibition of AKT phosphorylation in the IC before or after the first CTA retrieval test resulted in reduction in the aversion index. This reduction in aversion is due to the erasure of the original CTA trace memory, as re-application of the unconditioned stimulus (lithium chloride) did not induce the recovery of aversion in LY294002-treated animals. Our present data add new evidence to suggest that PI3K is engaged in consolidation of aversive memories, as its inhibition is associated with erasure of CTA memory.
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