ArticleMucosal immunology2013
γδT cells suppress inflammation and disease during rhinovirus-induced asthma exacerbations.
Article in Mucosal immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- γδ T Cells Are Required for the Induction of Sterile Immunity during Irradiated Sporozoite Vaccinations.Journal of immunology (Baltimore, Md. : 1950) · 2017Trial
- The Role of Innate T Cells in Inflammatory Disorders in Asthma and Chronic Rhinosinusitis.Clinical and experimental otorhinolaryngology · 2026Review
- The Major Role of Type 2 Inflammation in Asthma: From the Perspective of Immunological Mechanism.BioMed research international · 2026Review
- γδ T Cells and Allergic Diseases.Clinical reviews in allergy & immunology · 2023Review
- Inhibition of γ-glutamyl transferase suppresses airway hyperresponsiveness and airway inflammation in a mouse model of steroid resistant asthma exacerbation.Frontiers in immunology · 2023Article
- T-cell responses in asthma exacerbations.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
- Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations.Mucosal immunology · 2022Article
- Aerosol inhalation of Mycobacterium bovis can reduce the Th2 dominant immune response induced by ovalbumin sensitization.American journal of translational research · 2022Article
- γδ T Lymphocytes in Asthma: a Complicated Picture.Archivum immunologiae et therapiae experimentalis · 2021Review
- Innate-like Lymphocytes and Innate Lymphoid Cells in Asthma.Clinical reviews in allergy & immunology · 2020Review
- Regulation of γδT17 cells by Mycobacterium vaccae through interference with Notch/Jagged1 signaling pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- The Interplay between Host Immunity and Respiratory Viral Infection in Asthma Exacerbation.Immune network · 2019Review
- T cells in severe childhood asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Review
- Imbalance of γδT17/γδTreg cells in the pathogenesis of allergic asthma induced by ovalbumin.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Recent advances in understanding rhinovirus immunity.F1000Research · 2018Review
- Atopy-Dependent and Independent Immune Responses in the Heightened Severity of Atopics to Respiratory Viral Infections: Rat Model Studies.Frontiers in immunology · 2018Article
- Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia.Frontiers in immunology · 2018Review
- Spectrum of T-lymphocyte activities regulating allergic lung inflammation.Immunological reviews · 2017Review
- Tbet Deficiency Causes T Helper Cell Dependent Airways Eosinophilia and Mucus Hypersecretion in Response to Rhinovirus Infection.PLoS pathogens · 2016Article
- Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.Journal of translational medicine · 2016Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
Most asthma exacerbations are triggered by virus infections, the majority being caused by human rhinoviruses (RV). In mouse models, γδT cells have been previously demonstrated to influence allergen-driven airways hyper-reactivity (AHR) and can have antiviral activity, implicating them as prime candidates in the pathogenesis of asthma exacerbations. To explore this, we have used human and mouse models of experimental RV-induced asthma exacerbations to examine γδT-cell responses and determine their role in the immune response and associated airways disease. In humans, airway γδT-cell numbers were increased in asthmatic vs. healthy control subjects during experimental infection. Airway and blood γδT-cell numbers were associated with increased airways obstruction and AHR. Airway γδT-cell number was also positively correlated with bronchoalveolar lavage (BAL) virus load and BAL eosinophils and lymphocytes during RV infection. Consistent with our observations of RV-induced asthma exacerbations in humans, infection of mice with allergic airways inflammation increased lung γδT-cell number and activation. Inhibiting γδT-cell responses using anti-γδTCR (anti-γδT-cell receptor) antibody treatment in the mouse asthma exacerbation model increased AHR and airway T helper type 2 cell recruitment and eosinophilia, providing evidence that γδT cells are negative regulators of airways inflammation and disease in RV-induced asthma exacerbations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.