ArticleMolecules (Basel, Switzerland)2013
Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Novel Synthetic Chalcones Display Potent Anti-ACS omega · 2026Article
- Article
- Design, Synthesis, andACS omega · 2024Article
- Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids.Antioxidants (Basel, Switzerland) · 2021Review
- Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis.OncoTargets and therapy · 2021Review
- A chalcone derivative, 1m-6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation-induced endothelial dysfunction.British journal of pharmacology · 2020Article
- Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe.Chemical science · 2019Article
- In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways.Molecules (Basel, Switzerland) · 2019Article
- Chalcone Derivatives Enhance ATP-Binding Cassette Transporters A1 in Human THP-1 Macrophages.Molecules (Basel, Switzerland) · 2018Article
- QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity.European journal of medicinal chemistry · 2017Article
- Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum.Bioorganic & medicinal chemistry letters · 2017Article
- Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo.Molecules (Basel, Switzerland) · 2015Article
- Nephroprotective role of resveratrol and ursolic Acid in aristolochic Acid intoxicated zebrafish.Toxins · 2015Article
- Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model.Molecules (Basel, Switzerland) · 2014Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line "Tg(mpx:gfp)" to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
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