ArticleMarine drugs2013
Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Analysis Methods and Structure-Activity Relationships of Polysaccharides in Sea Cucumber: A Review.Marine drugs · 2026Review
- Therapeutic Potential of Sea Cucumber-Derived Bioactives in the Prevention and Management of Brain-Related Disorders: A Comprehensive Review.Marine drugs · 2025Review
- Proteomics Analysis of the Protective Effect of Polydeoxyribonucleotide Extracted from Sea Cucumber (Marine drugs · 2024Article
- Purification and Structural Analyses of Sulfated Polysaccharides from Low-Value Sea CucumberMarine drugs · 2024Article
- Structural Characterization and Anticoagulant Activities of a Keratan Sulfate-like Polysaccharide from the Sea CucumberMarine drugs · 2023Article
- Fucosylated Chondroitin Sulfates with Rare Disaccharide Branches from the Sea CucumbersPharmaceuticals (Basel, Switzerland) · 2023Article
- UHPLC-MS/MS metabolomics analysis of sea cucumber (Heliyon · 2023Article
- Detailed Structural Analysis of the Immunoregulatory Polysaccharides from the Mycobacterium Bovis BCG.Molecules (Basel, Switzerland) · 2022Article
- Critical Quality Control Methods for a Novel Anticoagulant Candidate LFG-Na by HPSEC-MALLS-RID and Bioactivity Assays.Molecules (Basel, Switzerland) · 2022Article
- Physicochemical Properties and Anticoagulant Activity of Purified Heteropolysaccharides fromMolecules (Basel, Switzerland) · 2022Article
- Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications.Marine drugs · 2022Review
- Structure Elucidation of Fucan Sulfate from Sea CucumberInternational journal of molecular sciences · 2022Article
- Carboxymethylation ofOxidative medicine and cellular longevity · 2022Article
- Isolation of Polysaccharides fromAntioxidants (Basel, Switzerland) · 2021Article
- Structural Characterization and Heparanase Inhibitory Activity of Fucosylated Glycosaminoglycan fromMarine drugs · 2021Article
- Hydrogel-Forming Algae Polysaccharides: From Seaweed to Biomedical Applications.Biomacromolecules · 2021Review
- Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders.Marine drugs · 2021Review
- Marine Bioactive Compounds as Nutraceutical and Functional Food Ingredients for Potential Oral Health.Frontiers in nutrition · 2021Review
- Comparison of Physicochemical Characteristics and Macrophage Immunostimulatory Activities of Polysaccharides fromMarine drugs · 2020Article
- A Glycosaminoglycan-Rich Fraction from Sea CucumberNutrients · 2020Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to search for sulfated polysaccharides in different invertebrate connective tissues and to examine their biological activities, we have isolated three types of polysaccharides from the body wall of the three sea cucumbers Holothuria edulis, Apostichopus japonicas and Holothuria nobilis. The physicochemical properties and anticoagulant activities of these polysaccharides were examined and compared. The chemical composition analysis and nuclear magnetic resonance (NMR) analysis indicate that two types of polysaccharides, sulfated fucan and fucosylated chondroitin sulfate (FuCS), were found in all of the three species and in addition a neutral glycan was observed in H. edulis. The neutral α-glucan was firstly obtained from sea cucumber. The same type of polysaccharides from different species of sea cucumbers have similar physicochemical properties and anticoagulant activities, but those of different types of glycans are significantly different, possibly due to their different monosaccharide compositions, electric charges and average molecular weights. The FuCSs have stronger anticoagulant activities than the sulfated fucans, although the molecular sizes of the FuCSs are lower than those of the sulfated fucans, whereas the neutral glucan has no activity, as expected from the absence of sulfate. Thus, anticoagulant activities of the different type of polysaccharides are likely to relate to monosaccharide composition and sulfate content. Preliminary analysis suggests that the sulfation patterns of the FuCSs may result in the difference in anticoagulant activities. Our data could help elucidate the structure-activity relationship of the sea cucumber polysaccharides.
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