ReviewCurrent opinion in neurobiology2013
Genetic approaches for understanding the role of serotonin receptors in mood and behavior.
Review in Current opinion in neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale.Cell · 2023Article
- Article
- Dissecting the Functional Organization of thebioRxiv : the preprint server for biology · 2023Article
- Deletion of the Serotonin Receptor 7 Gene Changed the Development and Behavior of the Mosquito,Insects · 2022Article
- Behavioral Effects of Exposure to Phthalates in Female Rodents: Evidence for Endocrine Disruption?International journal of molecular sciences · 2022Review
- Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans.WormBook : the online review of C. elegans biology · 2018Review
- Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts.Oncotarget · 2017Article
- Divergent Roles of Central Serotonin in Adult Hippocampal Neurogenesis.Frontiers in cellular neuroscience · 2017Review
- Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior.Pharmacological reviews · 2016Review
- Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice.Molecular brain · 2016Article
- The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription.Translational psychiatry · 2016Article
- Article
- DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS.Depression and anxiety · 2015Review
- Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-HT1A receptor.Lipids in health and disease · 2015Article
- Article
- Assessing neurocognitive function in psychiatric disorders: a roadmap for enhancing consensus.Neurobiology of learning and memory · 2014Article
- Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird.The Journal of experimental biology · 2014Article
- Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression.Frontiers in behavioral neuroscience · 2014Review
- Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms.Frontiers in behavioral neuroscience · 2014Review
- 50 years of hurdles and hope in anxiolytic drug discovery.Nature reviews. Drug discovery · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Serotonin (5-hydroxytryptamine; 5-HT) is an ancient signaling molecule that has a conserved role in modulating mood and behavior. Integral to its pleiotropic actions is the existence of multiple receptors, expressed in distinct but often overlapping patterns within the brain and the periphery. The existence of ∼14 mammalian receptor subtypes, many of which possess similar pharmacological profiles, has made assigning functional roles for these receptors challenging. This challenge has been further compounded by the revelation that a single receptor can have several different functions depending upon where and when it is expressed and activated, that is, in brain versus periphery, or at different developmental time points. This review highlights the contribution of genetic techniques to dissect the specific function of distinct serotonin receptor populations across the life course, with an emphasis on the contribution of different serotonin 1A receptor populations to mood and behavior. Similar approaches hold the promise to elucidate the functional roles of other receptors, as well as the interaction of serotonin with other neuroendocrine modulators of mood and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.