ArticleMolecular oncology2013
The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression.
Article in Molecular oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
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- Type 2 Diabetes Mellitus and Cardiovascular Disease: Genetic and Epigenetic Links.Frontiers in endocrinology · 2018Review
- Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide.Translational oncology · 2017Article
- High mobility group A1 protein modulates autophagy in cancer cells.Cell death and differentiation · 2017Article
- Critical role of HMGA proteins in cancer cell chemoresistance.Journal of molecular medicine (Berlin, Germany) · 2017Review
- miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene.BMC cancer · 2017Article
- MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase.Oncotarget · 2017Article
- Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways.Cancer research · 2016Article
- Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic.EMBO molecular medicine · 2016Article
- Article
- miR-198 Represses the Proliferation of HaCaT Cells by Targeting Cyclin D2.International journal of molecular sciences · 2015Article
- Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.Oncotarget · 2015Article
- Over-expression of miR-10b in NPC patients: correlation with LMP1 and Twist1.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Article
- MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma.Oncotarget · 2015Article
- RNA-Mediated Regulation of HMGA1 Function.Biomolecules · 2015Review
- The high mobility group A1 molecular switch: turning on cancer - can we turn it off?Expert opinion on therapeutic targets · 2014Review
- Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Correlated expression of HMGA2 and PLAG1 in thyroid tumors, uterine leiomyomas and experimental models.PloS one · 2014Article
Corrections and comments
- Correction · 2013-12-22Duplication of/in Image · · original article by Elsevier; Corrigendum by Wiley
- Erratum issued
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The overexpression of the HMGA1 proteins is a feature of human malignant neoplasias and has a causal role in cell transformation. The aim of our study has been to investigate the microRNAs (miRNAs or miRs) regulated by the HMGA1 proteins in the process of cell transformation analyzing the miRNA expression profile of v-ras-Ki oncogene-transformed thyroid cells expressing or not HMGA1 proteins. We demonstrate that, among the miRNAs regulated by cell transformation, there are miR-10b, miR-21, miR-125b, miR-221 and miR-222 that are positively and miR-34a and miR-603 that are negatively regulated by HMGA1 expression. Then, we focused our attention on the miR-10b and miR-603 whose expression was dependent on the presence of HMGA1 also in other cell systems. We found that miR-10b is able to target the PTEN gene, whereas miR-603 targets the CCND1 and CCND2 genes coding for the cyclin D1 and cyclin D2 proteins, respectively. Moreover, functional studies showed that miR-10b and miR-603 regulate positively and negatively, respectively, cell proliferation and migration suggesting a role of their dysregulation in thyroid cell transformation.
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