ArticleNeuroImage2013
Ultra high-resolution fMRI and electrophysiology of the rat primary somatosensory cortex.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- SORDINO: silent, sensitive, specific and artifact-resistant fMRI in awake, behaving mice.Nature neuroscience · 2026Article
- The Cerebellar Connectome.Cerebellum (London, England) · 2026Article
- Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Systematic evaluation of adhesives for implant fixation in multimodal functional brain MRI.Magma (New York, N.Y.) · 2025Article
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Distal activity patterns shape the spatial specificity of neurovascular coupling.Nature neuroscience · 2024Article
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats.Addiction neuroscience · 2023Article
- Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex.Human brain mapping · 2023Article
- The current status and trend of the functional magnetic resonance combined with stimulation in animals.Frontiers in neuroscience · 2022Article
- Contribution of animal models toward understanding resting state functional connectivity.NeuroImage · 2021Review
- One-pot synthesis of carboxymethyl-dextran coated iron oxide nanoparticles (CION) for preclinical fMRI and MRA applications.NeuroImage · 2021Article
- High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Dynamic Contrast Optical Coherence Tomography reveals laminar microvascular hemodynamics in the mouse neocortex in vivo.NeuroImage · 2019Article
- Foundations of layer-specific fMRI and investigations of neurophysiological activity in the laminarized neocortex and olfactory bulb of animal models.NeuroImage · 2019Review
- Laminar fMRI: What can the time domain tell us?NeuroImage · 2019Review
- Functional connectivity with cortical depth assessed by resting state fMRI of subregions of S1 in squirrel monkeys.Human brain mapping · 2019Article
- Layer-specific connectivity revealed by diffusion-weighted functional MRI in the rat thalamocortical pathway.NeuroImage · 2019Article
- Effects of Hemodynamic Response Function Selection on Rat fMRI Statistical Analyses.Frontiers in neuroscience · 2019Article
- Mapping stress networks using functional magnetic resonance imaging in awake animals.Neurobiology of stress · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
High-resolution functional-magnetic-resonance-imaging (fMRI) has been used to study brain functions at increasingly finer scale, but whether fMRI can accurately reflect layer-specific neuronal activities is less well understood. The present study investigated layer-specific cerebral-blood-volume (CBV) fMRI and electrophysiological responses in the rat cortex. CBV fMRI at 40×40 μm in-plane resolution was performed on an 11.7-T scanner. Electrophysiology used a 32-channel electrode array that spanned the entire cortical depth. Graded electrical stimulation was used to study activations in different cortical layers, exploiting the notion that most of the sensory-specific neurons are in layers II-V and most of the nociceptive-specific neurons are in layers V-VI. CBV response was strongest in layer IV of all stimulus amplitudes. Current source density analysis showed strong sink currents at cortical layers IV and VI. Multi-unit activities mainly appeared at layers IV-VI and peaked at layer V. Although our measures showed scaled activation profiles during modulation of stimulus amplitude and failed to detect specific recruitment at layers V and VI during noxious electrical stimuli, there appears to be discordance between CBV fMRI and electrophysiological peak responses, suggesting neurovascular uncoupling at laminar resolution. The technique implemented in the present study offers a means to investigate intracortical neurovascular function in the normal and diseased animal models at laminar resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.