ArticleBMC infectious diseases2013
Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Sexually transmitted enteric infections in men who have sex with men.Clinical microbiology reviews · 2025Review
- Carbapenemase Mechanism Testing to Support Treatment, Infection Control, and Public Health: The Role of the Clinical Laboratory.Clinics in laboratory medicine · 2025Review
- Molecular Surveillance of Multidrug-Resistant Bacteria among Refugees from Afghanistan in 2 US Military Hospitals during Operation Allies Refuge, 2021.Emerging infectious diseases · 2024Article
- Know your Microbe Foes: The Role of Surveillance in Combatting Antimicrobial Resistance.The Yale journal of biology and medicine · 2022Review
- Multidrug-Resistant and Virulent Organisms Trauma Infections: Trauma Infectious Disease Outcomes Study Initiative.Military medicine · 2022Review
- A systematic review of the impacts of oral tetracycline class antibiotics on antimicrobial resistance in normal human flora.JAC-antimicrobial resistance · 2022Review
- Article
- Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action.Molecules (Basel, Switzerland) · 2021Review
- Travel-associated multidrug-resistant organism acquisition and risk factors among US military personnel.Journal of travel medicine · 2021Observational
- Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- The Relative Impact of Community and Hospital Antibiotic Use on the Selection of Extended-spectrum Beta-lactamase-producing Escherichia coli.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Intestinal Carriage of Third-Generation Cephalosporin-Resistant and Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Healthy US Children.Journal of the Pediatric Infectious Diseases Society · 2018Article
- Early Infections Complicating the Care of Combat Casualties from Iraq and Afghanistan.Surgical infections · 2018Observational
- Bactericidal Property of Oregano Oil Against Multidrug-Resistant Clinical Isolates.Frontiers in microbiology · 2018Article
- The end of a dogma: the safety of doxycycline use in young children for malaria treatment.Malaria journal · 2017Review
- Antibiotics in malaria therapy: which antibiotics except tetracyclines and macrolides may be used against malaria?Malaria journal · 2016Review
- Microbiology and risk factors associated with war-related wound infections in the Middle East.Epidemiology and infection · 2016Review
- Lack of doxycycline antimalarial prophylaxis impact on Staphylococcus aureus tetracycline resistance.Diagnostic microbiology and infectious disease · 2016Observational
- The use of PCR/Electrospray Ionization-Time-of-Flight-Mass Spectrometry (PCR/ESI-TOF-MS) to detect bacterial and fungal colonization in healthy military service members.BMC infectious diseases · 2016Article
- Multidrug-resistant gram-negative bacilli colonization risk factors among trauma patients.Diagnostic microbiology and infectious disease · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe US military has seen steady increases in multidrug-resistant (MDR) gram-negative bacteria (GNB) infections in casualties from Iraq and Afghanistan. This study evaluates the prevalence of MDR GNB colonization in US military personnel.
methodsGNB colonization surveillance of healthy, asymptomatic military personnel (101 in the US and 100 in Afghanistan) was performed by swabbing 7 anatomical sites. US-based personnel had received no antibiotics within 30 days of specimen collection, and Afghanistan-based personnel were receiving doxycycline for malaria chemoprophylaxis at time of specimen collection. Isolates underwent genotypic and phenotypic characterization.
resultsThe only colonizing MDR GNB recovered in both populations was Escherichia coli (p=0.01), which was seen in 2% of US-based personnel (all perirectal) and 11% of Afghanistan-based personnel (10 perirectal, 1 foot+groin). Individuals with higher off-base exposures in Afghanistan did not show a difference in overall GNB colonization or MDR E. coli colonization, compared with those with limited off-base exposures.
conclusionHealthy US- and Afghanistan-based military personnel have community onset-MDR E. coli colonization, with Afghanistan-based personnel showing a 5.5-fold higher prevalence. The association of doxycycline prophylaxis or other exposures with antimicrobial resistance and increased rates of MDR E. coli colonization needs further evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.