ArticleACS applied materials & interfaces2013
Interfacial thiol-ene photoclick reactions for forming multilayer hydrogels.
Article in ACS applied materials & interfaces, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Smart Polymer-Derived Injectable Hydrogels: Current Status and Future Perspectives.ACS polymers Au · 2025Review
- Highlighting the Influence between Physical and Chemical Cross-Linking in Dynamic Hydrogels for Two-Photon Micropatterning.Biomacromolecules · 2025Article
- Photocrosslinkable Biomaterials for 3D Bioprinting: Mechanisms, Recent Advances, and Future Prospects.International journal of molecular sciences · 2024Review
- Poly(ethylene glycol)-Norbornene as a Photoclick Bioink for Digital Light Processing 3D Bioprinting.ACS applied materials & interfaces · 2023Article
- Review
- A disulfide-based linker for thiol-norbornene conjugation: formation and cleavage of hydrogels by the use of light.Polymer chemistry · 2022Article
- Hydrogel Production Platform with Dynamic Movement Using Photo-Crosslinkable/Temperature Reversible Chitosan Polymer and Stereolithography 4D Printing Technology.Tissue engineering and regenerative medicine · 2020Article
- Dynamic PEG-Peptide Hydrogels via Visible Light and FMN-Induced Tyrosine Dimerization.Advanced healthcare materials · 2018Article
- Core-shell patterning of synthetic hydrogelsChemical science · 2018Article
- Review
- In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels.Biomaterials science · 2017Article
- Dual-pathway chain-end modification of RAFT polymers using visible light and metal-free conditions.Chemical communications (Cambridge, England) · 2017Article
- Modular and Adaptable Tumor Niche Prepared from Visible Light Initiated Thiol-Norbornene Photopolymerization.Biomacromolecules · 2016Article
- Thiol-ene Photocrosslinking of Cytocompatible Resilin-Like Polypeptide-PEG Hydrogels.Macromolecular bioscience · 2016Article
- Photoclick Hydrogels Prepared from Functionalized Cyclodextrin and Poly(ethylene glycol) for Drug Delivery and in Situ Cell Encapsulation.Biomacromolecules · 2015Article
- Modular and orthogonal synthesis of hybrid polymers and networks.Chemical communications (Cambridge, England) · 2015Review
- Thiol-norbornene photo-click hydrogels for tissue engineering applications.Journal of applied polymer science · 2015Article
- Recent advances in crosslinking chemistry of biomimetic poly(ethylene glycol) hydrogels.RSC advances · 2015Article
- Visible light cured thiol-vinyl hydrogels with tunable degradation for 3D cell culture.Acta biomaterialia · 2014Article
- Visible light-initiated interfacial thiol-norbornene photopolymerization for forming islet surface conformal coating.Journal of materials chemistry. BArticle
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3 authors.
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Abstract
Interfacial visible light-mediated thiol-ene photoclick reactions were developed for preparing step-growth hydrogels with multilayer structures. The effect of a noncleavage type photoinitiator eosin-Y on visible-light-mediated thiol-ene photopolymerization was first characterized using in situ photorheometry, gel fraction, and equilibrium swelling ratio. Next, spectrophotometric properties of eosin-Y in the presence of various relevant macromer species were evaluated using ultraviolet-visible light (UV-vis) spectrometry. It was determined that eosin-Y was able to reinitiate the thiol-ene photoclick reaction, even after light exposure. Because of its small molecular weight, most eosin-Y molecules readily leached out from the hydrogels. The diffusion of residual eosin-Y from preformed hydrogels was exploited for fabricating multilayer step-growth hydrogels. Interfacial hydrogel coating was formed via the same visible-light-mediated gelation mechanism without adding fresh initiator. The thickness of the thiol-ene gel coating could be easily controlled by adjusting visible light exposure time, eosin-Y concentration initially loaded in the core gel, or macromer concentration in the coating solution. The major benefits of this interfacial thiol-ene coating system include its simplicity and cytocompatibility. The formation of thiol-ene hydrogels and coatings neither requires nor generates any cytotoxic components. This new gelation chemistry may have great utilities in controlled release of multiple sensitive growth factors and encapsulation of multiple cell types for tissue regeneration.
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