ArticlePhysical review letters2013
Stress-enhanced gelation: a dynamic nonlinearity of elasticity.
Article in Physical review letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers.iScience · 2023Article
- Simulations of dynamically cross-linked actin networks: Morphology, rheology, and hydrodynamic interactions.PLoS computational biology · 2021Article
- Article
- Binding Dynamics of α-Actinin-4 in Dependence of Actin Cortex Tension.Biophysical journal · 2020Article
- Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Active Prestress Leads to an Apparent Stiffening of Cells through Geometrical Effects.Biophysical journal · 2018Article
- Mechanical Properties of the Cytoskeleton and Cells.Cold Spring Harbor perspectives in biology · 2017Review
- Local dynamic mechanical analysis for heterogeneous soft matter using ferrule-top indentation.Soft matter · 2016Article
- Synaptopodin couples epithelial contractility to α-actinin-4-dependent junction maturation.The Journal of cell biology · 2015Article
- Forcing cells into shape: the mechanics of actomyosin contractility.Nature reviews. Molecular cell biology · 2015Review
- Alpha-actinin binding kinetics modulate cellular dynamics and force generation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Cells as liquid motors: mechanosensitivity emerges from collective dynamics of actomyosin cortex.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mimicking the mechanical properties of the cell cortex by the self-assembly of an actin cortex in vesicles.Applied physics letters · 2014Article
- Molecular mechanisms of cellular mechanosensing.Nature materials · 2013Article
- Effects of non-linearity on cell-ECM interactions.Experimental cell research · 2013Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A hallmark of biopolymer networks is their sensitivity to stress, reflected by pronounced nonlinear elastic stiffening. Here, we demonstrate a distinct dynamical nonlinearity in biopolymer networks consisting of filamentous actin cross-linked by α-actinin-4. Applied stress delays the onset of relaxation and flow, markedly enhancing gelation and extending the regime of solidlike behavior to much lower frequencies. We show that this macroscopic network response can be accounted for at the single molecule level by the increased binding affinity of the cross-linker under load, characteristic of catch-bond-like behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.