ArticlePhysical review letters2013
Theoretical and experimental dissection of DNA loop-mediated repression.
Article in Physical review letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Flexibility and sensitivity in gene regulation out of equilibrium.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transcription factor competition facilitates self-sustained oscillations in single gene genetic circuits.PLoS computational biology · 2023Article
- Article
- Robustness of DNA looping across multiple cell divisions in individual bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Anticipating response function in gene regulatory networks.Journal of the Royal Society, Interface · 2021Article
- Reconciling kinetic and thermodynamic models of bacterial transcription.PLoS computational biology · 2021Article
- Figure 1 Theory Meets Figure 2 Experiments in the Study of Gene Expression.Annual review of biophysics · 2019Review
- Tuning Transcriptional Regulation through Signaling: A Predictive Theory of Allosteric Induction.Cell systems · 2018Article
- The free-energy cost of interaction between DNA loops.Scientific reports · 2017Article
- Genetic cargo and bacterial species set the rate of vesicle-mediated horizontal gene transfer.Scientific reports · 2017Article
- Self-consistent theory of transcriptional control in complex regulatory architectures.PloS one · 2017Article
- Effect of Interaction between Chromatin Loops on Cell-to-Cell Variability in Gene Expression.PLoS computational biology · 2016Article
- Using synthetic biology to make cells tomorrow's test tubes.Integrative biology : quantitative biosciences from nano to macro · 2016Review
- High-resolution specificity from DNA sequencing highlights alternative modes of Lac repressor binding.Genetics · 2014Article
- Comparison of the theoretical and real-world evolutionary potential of a genetic circuit.Physical biology · 2014Article
- Statistical mechanical model of coupled transcription from multiple promoters due to transcription factor titration.Physical review. E, Statistical, nonlinear, and soft matter physics · 2014Article
- DNA sequence-dependent mechanics and protein-assisted bending in repressor-mediated loop formation.Physical biology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Transcriptional networks across all domains of life feature a wide range of regulatory architectures. Theoretical models now make clear predictions about how key parameters describing those architectures modulate gene expression, and the ability to construct genetic circuits with tunable parameters enables precise tests of such models. We dissect gene regulation through DNA looping by tuning network parameters such as repressor copy number, DNA binding strengths, and loop length in both thermodynamic models and experiments. Our results help clarify the short-length mechanical properties of DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.