Evidence map›Paper›PMID 23383717›Full record

ArticleBiometrics2013

A semiparametric censoring bias model for estimating the cumulative risk of a false-positive screening test under dependent censoring.

Rebecca A Hubbard, Diana L Miglioretti

Abstract read
In one paragraph

Article in Biometrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Performance of Statistical and Machine Learning Risk Prediction Models for Advanced Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  2. Performance of Statistical and Machine Learning Risk Prediction Models for Surveillance Benefits and Failures in Breast Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Statistical Methods for Estimating the Cumulative Risk of Screening Mammography Outcomes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
    Article
  9. The cumulative risk of false-positive fecal occult blood test after 10 years of colorectal cancer screening.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Rebecca A HubbardBiostatistics Unit, Group Health Research Institute, Seattle, Washington 98101, USA. hubbard.r@ghc.org
Diana L Miglioretti

Funding

Risk-based Imaging Strategies to Improve Breast Cancer Surveillance OutcomesP01CA154292 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Diana L Miglioretti · 2011 to 2026
$52.9M
Statistical Coordinating Center for the Breast Cancer Surveillance ConsortiumU01CA086076 · NCI · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI MIGLIORETTI, DIANA L · 2000 to 2011
$8.5M
IMPROVING THE QUALITY OF MAMMOGRAPHIC INTERPRETATIONU01CA063731 · NCI · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI BUIST, DIANA SM · 1994 to 2011
$6.7M
VERMONT BREAST CANCER SURVEILLANCE SYSTEMU01CA070013 · NCI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GELLER, BERTA M · 1995 to 2011
$6.7M
UTILITY AND OUTCOMES FROM MAMMOGRAPHY IN NORTH CAROLINAU01CA070040 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YANKASKAS, BONNIE C · 1995 to 2011
$6.4M
San Francisco Mammography Registry-A Research SourceU01CA063740 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KERLIKOWSKE, KARLA M · 1994 to 2011
$6.2M
STRATEGIC STUDIES IN BREAST CANCER SURVEILLANCEU01CA086082 · NCI · DARTMOUTH COLLEGE · PI ONEGA, TRACY · 2000 to 2011
$4.9M
REFERRAL PATTERNS AND COST ANALYSIS OF SCREENING MAMMOGRAPHY--FOLLOW-UP/BIOPSYU01CA063736 · NCI · COOPER INSTITUTE · PI CUTTER, GARY · 1994 to 2004
$2.7M
NEW MEXICO MAMMOGRAPHY PROJECTU01CA069976 · NCI · UNIVERSITY OF NEW MEXICO · PI ROSENBERG, ROBERT D · 1995 to 2005
$2.7M
Comparative effectiveness of breast imaging strategies in community practiceRC2CA148577 · NCI · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI BUIST, DIANA SM, GELLER, BERTA M · 2009 to 2009
$2.0M
Estimating the cumulative risk of a false-positive screening mammogram.R03CA150007 · NCI · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI HUBBARD, REBECCA · 2010 to 2011
$158k
NCI NIH HHS HHSN261201100031CNCI NIH HHS P01 CA154292NCI NIH HHS R03 CA150007NCI NIH HHS R03CA150007NCI NIH HHS RC2 CA148577NCI NIH HHS RC2CA148577NCI NIH HHS U01 CA063731NCI NIH HHS U01 CA063736NCI NIH HHS U01 CA063740NCI NIH HHS U01 CA069976NCI NIH HHS U01 CA070013NCI NIH HHS U01 CA070040NCI NIH HHS U01 CA086076NCI NIH HHS U01 CA086082NCI NIH HHS U01CA63731NCI NIH HHS U01CA63736NCI NIH HHS U01CA63740NCI NIH HHS U01CA69976NCI NIH HHS U01CA70013NCI NIH HHS U01CA70040NCI NIH HHS U01CA86076NCI NIH HHS U01CA86082
6 · The paper itself

Abstract

False-positive test results are among the most common harms of screening tests and may lead to more invasive and expensive diagnostic testing procedures. Estimating the cumulative risk of a false-positive screening test result after repeat screening rounds is, therefore, important for evaluating potential screening regimens. Existing estimators of the cumulative false-positive risk are limited by strong assumptions about censoring mechanisms and parametric assumptions about variation in risk across screening rounds. To address these limitations, we propose a semiparametric censoring bias model for cumulative false-positive risk that allows for dependent censoring without specifying a fixed functional form for variation in risk across screening rounds. Simulation studies demonstrated that the censoring bias model performs similarly to existing models under independent censoring and can largely eliminate bias under dependent censoring. We used the existing and newly proposed models to estimate the cumulative false-positive risk and variation in risk as a function of baseline age and family history of breast cancer after 10 years of annual screening mammography using data from the Breast Cancer Surveillance Consortium. Ignoring potential dependent censoring in this context leads to underestimation of the cumulative risk of false-positive results. Models that provide accurate estimates under dependent censoring are critical for providing appropriate information for evaluating screening tests.

Indexed as

False Positive ReactionsModels, StatisticalRiskAdultBreast NeoplasmsComputer SimulationFemaleHumansMammographyMass ScreeningMiddle Aged

Identifiers

PMID23383717
PMCPMC3622119

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.