ArticlePloS one2013
Phenotyping of left and right ventricular function in mouse models of compensated hypertrophy and heart failure with cardiac MRI.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Automated cardiac MRI analysis for robust profiling of heart failure models in mice.Scientific reports · 2025Article
- Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury.Biology of sex differences · 2025Article
- Biomedical Imaging in Experimental Models of Cardiovascular Disease.Circulation research · 2022Review
- Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models.Circulation research · 2022Review
- Structural and functional alterations in heart and skeletal muscle following severe TAC in mice: impact of moderate exercise training.Biological research · 2021Article
- Serelaxin Improves Regional Myocardial Function in Experimental Heart Failure: An In Vivo Cardiac Magnetic Resonance Study.Journal of the American Heart Association · 2020Article
- Non-invasive thermal imaging of cardiac remodeling in mice.Biomedical optics express · 2019Article
- Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea.Journal of cardiovascular translational research · 2019Article
- Pathophysiological Mapping of Experimental Heart Failure: Left and Right Ventricular Remodeling in Transverse Aortic Constriction Is Temporally, Kinetically and Structurally Distinct.Frontiers in physiology · 2018Article
- Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy.Circulation. Heart failure · 2017Article
- Article
- In vivo mouse myocardial (31)P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations.NMR in biomedicine · 2015Article
- Speckle tracking echocardiography assessment of global and regional contraction dysfunction in the mice model of pressure overload.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2015Article
- High throughput phenotyping of left and right ventricular cardiomyopathy in calcineurin transgene mice.The international journal of cardiovascular imaging · 2015Article
- [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction.Biomaterials · 2015Article
- Assessment of Myocardial Fibrosis in Mice Using a T2*-Weighted 3D Radial Magnetic Resonance Imaging Sequence.PloS one · 2015Article
- Swine model of chronic postcapillary pulmonary hypertension with right ventricular remodeling: long-term characterization by cardiac catheterization, magnetic resonance, and pathology.Journal of cardiovascular translational research · 2014Article
- Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.The Journal of clinical investigation · 2014Article
- Myocardial perfusion MRI shows impaired perfusion of the mouse hypertrophic left ventricle.The international journal of cardiovascular imaging · 2014Article
- Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft ventricular (LV) and right ventricular (RV) function have an important impact on symptom occurrence, disease progression and exercise tolerance in pressure overload-induced heart failure, but particularly RV functional changes are not well described in the relevant aortic banding mouse model. Therefore, we quantified time-dependent alterations in the ventricular morphology and function in two models of hypertrophy and heart failure and we studied the relationship between RV and LV function during the transition from hypertrophy to heart failure.
methodsMRI was used to quantify RV and LV function and morphology in healthy (n = 4) and sham operated (n = 3) C57BL/6 mice, and animals with a mild (n = 5) and a severe aortic constriction (n = 10).
resultsMice subjected to a mild constriction showed increased LV mass (P<0.01) and depressed LV ejection fraction (EF) (P<0.05) as compared to controls, but had similar RVEF (P>0.05). Animals with a severe constriction progressively developed LV hypertrophy (P<0.001), depressed LVEF (P<0.001), followed by a declining RVEF (P<0.001) and the development of pulmonary remodeling, as compared to controls during a 10-week follow-up. Myocardial strain, as a measure for local cardiac function, decreased in mice with a severe constriction compared to controls (P<0.05).
conclusionsRelevant changes in mouse RV and LV function following an aortic constriction could be quantified using MRI. The well-controlled models described here open opportunities to assess the added value of new MRI techniques for the diagnosis of heart failure and to study the impact of new therapeutic strategies on disease progression and symptom occurrence.
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