ArticlePloS one2013
Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of angiotensin receptors.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Role of Iberin as an anti-apoptotic agent on renal ischemia-reperfusion injury in rats.Journal of medicine and life · 2023Article
- Simvastatin Improves Myocardial Ischemia Reperfusion Injury through KLF-Regulated Alleviation of Inflammation.Disease markers · 2022Article
- Overfeeding During Lactation in Rats is Associated with Cardiovascular Insulin Resistance in the Short-Term.Nutrients · 2020Article
- Overweight during lactation and its implications for biometric, nutritional and cardiovascular parameters of young and adult male and female rats.Journal of nutritional science · 2020Article
- Aged (Black) versus Raw Garlic against Ischemia/Reperfusion-Induced Cardiac Complications.International journal of molecular sciences · 2018Article
- Article
- High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury.Cardiovascular diabetology · 2014Article
- Long-term effects of early overnutrition in the heart of male adult rats: role of the renin-angiotensin system.PloS one · 2014Article
- Antiapoptotic effect of simvastatin ameliorates myocardial ischemia/reperfusion injury.ISRN pharmacology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity during childhood has dramatically increased worldwide in the last decades. Environmental factors acting early in life, including nutrition, play an important role in the pathogenesis of obesity and cardiovascular diseases in adulthood.
aimsTo analyze the effects of early overfeeding on the heart and coronary circulation, the effect of ischemia-reperfusion (I/R) and the role of the renin-angiotensin system (RAS) were studied in isolated hearts from control and overfed rats during lactation. METHODS AND
resultsOn the day of birth litters were adjusted to twelve pups per mother (control) or to three pups per mother (overfed). At weaning (21 days) the rats were killed and the heart perfused in a Langendorff system and subjected to 30 min of ischemia followed by 15 min of reperfusion. The contractility (left developed intraventricular pressure) was lower in the hearts from overfed rats, and was reduced by I/R in hearts from control but not from overfed rats. I/R also reduced the coronary vasoconstriction to angiotensin II more in hearts from control than from overfed rats, and the vasodilatation to bradykinin similarly in both experimental groups. The expression of both angiotensin AGTRa and AGTR2 receptors was increased in the myocardium of overfed rats, and I/R increased the expression of both receptors in control rats but reduced it in overfed rats. The expression of apoptotic and antiapoptotic markers was increased in hearts of overfed rats compared with control, and further increased by I/R.
conclusionsThese results suggest that both overfeeding and I/R impair cardiac and coronary function due, at least in part, to activation of the angiotensin pathway. However, overfeeding may reduce the impairment of ventricular contractility by I/R.
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