ArticlePloS one2013
Hyaluronic acid induces activation of the κ-opioid receptor.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Mechanism of action behind the pain-relief effects of extracellular vesicles in microfragmented adipose tissue: an in vitro and in vivo study.Journal of translational medicine · 2025Article
- Deciphering the role of glycosaminoglycans in GPCR signaling.Cellular signalling · 2024Review
- Pain Management Strategies in Osteoarthritis.Biomedicines · 2024Review
- Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells.Nature cell biology · 2022Article
- Matters of size: Roles of hyaluronan in CNS aging and disease.Ageing research reviews · 2021Review
- Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model: a randomized controlled trial.Journal of orthopaedic surgery and research · 2021Article
- Comparative matched-pair cohort analysis of the short-term clinical outcomes of mesenchymal stem cells versus hyaluronic acid treatments through intra-articular injections for knee osteoarthritis.Journal of experimental orthopaedics · 2020Article
- Hyaluronic Acid Combined with Serum Rich in Growth Factors in Corneal Epithelial Defects.International journal of molecular sciences · 2019Article
- The Disease-Modifying Effects of Hyaluronan in the Osteoarthritic Disease State.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2017Review
- Effect of enzymatic debridement with two different collagenases versus mechanical debridement on chronic hard-to-heal wounds.International wound journal · 2016Article
- Hyaluronic acid induces the release of growth factors from platelet-rich plasma.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2016Article
- Intra-articular hyaluronic acid is superior to steroids in knee osteoarthritis: A comparative, randomized study.Journal of clinical orthopaedics and traumaArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionNociceptive pain is one of the most common types of pain that originates from an injury involving nociceptors. Approximately 60% of the knee joint innervations are classified as nociceptive. The specific biological mechanism underlying the regulation of nociceptors is relevant for the treatment of symptoms affecting the knee joint. Intra-articular administration of exogenous hyaluronic acid (HA) in patients with osteoarthritis (OA) appears to be particularly effective in reducing pain and improving patient function.
methodsWe performed an in vitro study conducted in CHO cells that expressed a panel of opioid receptors and in primary rat dorsal root ganglion (DRG) neurons to determine if HA induces the activation of opioid peptide receptors (OPr) using both aequorin and the fluorescent dye Fura-2/AM.
resultsSelective agonists and antagonists for each OPr expressed on CHO cells were used to test the efficacy of our in vitro model followed by stimulation with HA. The results showed that HA induces stimulatory effects on the κ receptor (KOP). These effects of HA were also confirmed in rat DRG neurons, which express endogenously the OPr.
conclusionsHA activates the KOP receptor in a concentration dependent manner, with a pEC(50) value of 7.57.
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