ArticlePloS one2013
Differences in X-chromosome transcriptional activity and cholesterol metabolism between placentae from swine breeds from Asian and Western origins.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Identification and Characterization of lncRNA and mRNA in Testes of Landrace and Hezuo Boars.Animals : an open access journal from MDPI · 2021Article
- Article
- No imprinted XIST expression in pigs: biallelic XIST expression in early embryos and random X inactivation in placentas.Cellular and molecular life sciences : CMLS · 2019Article
- Genome-wide identification and characterization of long non-coding RNAs expressed during sheep fetal and postnatal hair follicle development.Scientific reports · 2019Article
- Genome-Wide Identification of Histone Modifications Involved in Placental Development in Pigs.Frontiers in genetics · 2019Article
- Analysis of Long Non-Coding RNA and mRNA Expression Profiling in Immature and Mature Bovine (Frontiers in genetics · 2019Article
- Polymorphism in the intron 20 of porcine O-linked N-acetylglucosamine transferase.Asian-Australasian journal of animal sciences · 2017Article
- Systematic Analysis of Long Noncoding RNAs in the Senescence-accelerated Mouse Prone 8 Brain Using RNA Sequencing.Molecular therapy. Nucleic acids · 2016Article
- Difference in expression patterns of placental cholesterol transporters, ABCA1 and SR-BI, in Meishan and Yorkshire pigs with different placental efficiency.Scientific reports · 2016Article
- Genetic determinants of pig birth weight variability.BMC genetics · 2016Article
- Identification of the porcine XIST gene and its differential CpG methylation status in male and female pig cells.PloS one · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
To gain insight into differences in placental physiology between two swine breeds noted for their dissimilar reproductive performance, that is, the Chinese Meishan and white composite (WC), we examined gene expression profiles of placental tissues collected at 25, 45, 65, 85, and 105 days of gestation by microarrays. Using a linear mixed model, a total of 1,595 differentially expressed genes were identified between the two pig breeds using a false-discovery rate q-value ≤0.05. Among these genes, we identified breed-specific isoforms of XIST, a long non-coding RNA responsible X-chromosome dosage compensation in females. Additionally, we explored the interaction of placental gene expression and chromosomal location by DIGMAP and identified three Sus scrofa X chromosomal bands (Xq13, Xq21, Xp11) that represent transcriptionally active clusters that differ between Meishan and WC during placental development. Also, pathway analysis identified fundamental breed differences in placental cholesterol trafficking and its synthesis. Direct measurement of cholesterol confirmed that the cholesterol content was significantly higher in the Meishan versus WC placentae. Taken together, this work identifies key metabolic pathways that differ in the placentae of two swine breeds noted for differences in reproductive prolificacy.
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