ArticlePloS one2013
Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Vertical Transmission of Hepatitis B and C-Then and Now-A Comprehensive Literature Systematic Review.Viruses · 2025Pooled it
- Breastfeeding and the Risk of Infant Illness in Asia: A Review.International journal of environmental research and public health · 2019Pooled it
- KASL clinical practice guidelines for management of chronic hepatitis B.Clinical and molecular hepatology · 2019Guideline
- KASL clinical practice guidelines for management of chronic hepatitis B Endorsed by the East Asia Liver Alliance (EALA).Clinical and molecular hepatology · 2026Article
- Factors associated with hepatitis B mother-to-child transmission in a national prevention program.Clinical and molecular hepatology · 2025Article
- Recent Advancements and Best Practices in Supporting Newborn Feeding: A Narrative Review.Pediatric clinics of North America · 2025Review
- Elective cesarean section and bottle-feeding do not reduce infection of hepatitis B in infants of high viremic mothers: a retrospective study.BMC pregnancy and childbirth · 2025Article
- HBV Transmission Knowledge Among Korean-American Chronic Hepatitis B Patients in the United States.Journal of community health · 2025Article
- Is health, growth and development impaired in children who are Hepatitis B-exposed but uninfected?PLOS global public health · 2025Review
- Exploring the impact of hepatitis B immunoglobulin and antiviral interventions to reduce vertical transmission of hepatitis B virus.World journal of experimental medicine · 2024Review
- Identifying Childhood Risk Factors for Hepatitis B with a Focus on Vertical Transmission.Diseases (Basel, Switzerland) · 2024Article
- Vertical Transmission of Hepatitis B Virus-An Update.Microorganisms · 2023Review
- Management Algorithm for Prevention of Mother-to-child Transmission of Hepatitis B Virus (2022).Journal of clinical and translational hepatology · 2022Article
- Article
- Article
- Chronic hepatitis B in pregnant women: Current trends and approaches.World journal of gastroenterology · 2021Review
- [Management algorithm for prevention of mother-to-child transmission of hepatitis B virus (2021)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021Article
- Article
- Paediatric Virology and its interaction between basic science and clinical practice (Review).International journal of molecular medicine · 2018Review
- Mechanisms and Prevention of Vertical Transmission in Chronic Viral Hepatitis.Journal of clinical and translational hepatology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany clinicians do not encourage breastfeeding in hepatitis B virus (HBV) carriers, since HBV DNA can be detected in breast milk and breast lesions may increase exposure of infants to HBV. The aim of this study was to determine whether breastfeeding may add risk for perinatal HBV transmission. METHODOLOGY/PRINCIPAL
findingsTotally 546 children (1-7-year-old) of 544 HBV-infected mothers were investigated, with 397 breastfed and 149 formula-fed; 137 were born to HBeAg-positive mothers. All children had been vaccinated against hepatitis B but only 53.3% received hepatitis B immune globulin (HBIG). The overall prevalence of HBsAg+, HBsAg-/anti-HBc+, and anti-HBs (≥10 mIU/ml) in children was 2.4%, 3.1%, and 71.6% respectively. The HBsAg prevalence in breast- and formula-fed children was 1.5% and 4.7% respectively (P = 0.063); the difference was likely due to the higher mothers' HBeAg-positive rate in formula-fed group (formula-fed 49.0% vs. breastfed 15.9%, P<0.001). Further logistic regression analyses showed that breastfeeding was not associated with the HBV infection in the children, adjusting for the effect of maternal HBeAg status and other factors different between the two groups. CONCLUSIONS/SIGNIFICANCE: Under the recommended prophylaxis, breastfeeding is not a risk factor for mother-to-child transmission of HBV. Therefore, clinicians should encourage HBV-infected mothers to breastfeed their infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.