ArticlePloS one2013
Structural and phylogenetic analysis of laccases from Trichoderma: a bioinformatic approach.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- Isolation and Characterization of Laccase fromBiology · 2025Article
- Isolation, characterization, and mycostimulation of fungi for the degradation of polycyclic aromatic hydrocarbons at a superfund site.Biodegradation · 2025Article
- Precision Thermostability Predictions: Leveraging Machine Learning for Examining Laccases and Their Associated Genes.International journal of molecular sciences · 2024Article
- Purification, characterization and three-dimensional structure prediction of multicopper oxidase Laccases from Trichoderma lixii FLU1 and Talaromyces pinophilus FLU12.Scientific reports · 2024Article
- Competitive antagonistic action of laccase betweenFrontiers in microbiology · 2024Article
- Identification of laccase genes in Trichoderma asperellum Ts93.Biotechnology letters · 2023Article
- Effect of Biocides on the Activity of Extracellular Enzymes Produced by Degrader Fungi from Technical Objects Used in Tropical Climates (Vietnam).Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2022Article
- Autophagy-Related GeneInternational journal of molecular sciences · 2022Article
- Screening and evaluation of laccase produced by different Trichoderma species along with their phylogenetic relationship.Archives of microbiology · 2021Article
- The Mitogen-Activated Protein Kinase PlMAPK2 Is Involved in Zoosporogenesis and Pathogenicity ofInternational journal of molecular sciences · 2021Article
- Optimisation of the Production and Bleaching Process for a New Laccase from Madurella mycetomatis, Expressed in Pichia pastoris: from Secretion to Yielding Prominent.Molecular biotechnology · 2021Article
- Comparative Genomics Platform and Phylogenetic Analysis of Fungal Laccases and Multi-Copper Oxidases.Mycobiology · 2020Article
- Genome Sequence ofMicroorganisms · 2020Article
- Manganese (II) removal from aqueous solutions byBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Lignin degradation: microorganisms, enzymes involved, genomes analysis and evolution.FEMS microbiology reviews · 2017Review
- Lessons from characterization and treatment of the autoinflammatory syndromes.Current opinion in rheumatology · 2017Review
- Phylogenomic analyses reveal the diversity of laccase-coding genes in Fonsecaea genomes.PloS one · 2017Article
- Xenobiotic Compounds Degradation by Heterologous Expression of a Trametes sanguineus Laccase in Trichoderma atroviride.PloS one · 2016Article
- Biodegradation of polycyclic aromatic hydrocarbons by Trichoderma species: a mini review.Environmental science and pollution research international · 2015Review
- Diversity of laccase-coding genes in Fusarium oxysporum genomes.Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genus Trichoderma includes species of great biotechnological value, both for their mycoparasitic activities and for their ability to produce extracellular hydrolytic enzymes. Although activity of extracellular laccase has previously been reported in Trichoderma spp., the possible number of isoenzymes is still unknown, as are the structural and functional characteristics of both the genes and the putative proteins. In this study, the system of laccases sensu stricto in the Trichoderma species, the genomes of which are publicly available, were analyzed using bioinformatic tools. The intron/exon structure of the genes and the identification of specific motifs in the sequence of amino acids of the proteins generated in silico allow for clear differentiation between extracellular and intracellular enzymes. Phylogenetic analysis suggests that the common ancestor of the genus possessed a functional gene for each one of these enzymes, which is a characteristic preserved in T. atroviride and T. virens. This analysis also reveals that T. harzianum and T. reesei only retained the intracellular activity, whereas T. asperellum added an extracellular isoenzyme acquired through horizontal gene transfer during the mycoparasitic process. The evolutionary analysis shows that in general, extracellular laccases are subjected to purifying selection, and intracellular laccases show neutral evolution. The data provided by the present study will enable the generation of experimental approximations to better understand the physiological role of laccases in the genus Trichoderma and to increase their biotechnological potential.
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