ArticlePloS one2013
Increased childhood mortality and arsenic in drinking water in Matlab, Bangladesh: a population-based cohort study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Drinking water and the implications for gender equity and empowerment: A systematic review of qualitative and quantitative evidence.International journal of hygiene and environmental health · 2023Pooled it
- Prenatal arsenite exposure alters maternal cardiac remodeling during late pregnancy.Toxicology and applied pharmacology · 2024Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Defining high confidence targets of differential CpG methylation in response to in utero arsenic exposure and implications for cancer risk.Toxicology and applied pharmacology · 2024Article
- Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction.International journal of environmental research and public health · 2021Article
- Sex-Specific Effects of Prenatal and Early Life Inorganic and Methylated Arsenic Exposure on Atherosclerotic Plaque Development and Composition in AdultEnvironmental health perspectives · 2021Article
- Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health.Frontiers in toxicology · 2021Review
- Health Effects Associated With Pre- and Perinatal Exposure to Arsenic.Frontiers in genetics · 2021Review
- Early-Life Arsenic Exposure, Nutritional Status, and Adult Diabetes Risk.Current diabetes reports · 2019Review
- Impact of prenatal arsenic exposure on chronic adult diseases.Systems biology in reproductive medicine · 2018Review
- Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic.Current environmental health reports · 2018Review
- Chronic early childhood exposure to arsenic is associated with a TNF-mediated proteomic signaling response.Environmental toxicology and pharmacology · 2017Article
- Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh.PloS one · 2017Article
- Arsenic exposure and the seroprevalence of total hepatitis A antibodies in the US population: NHANES, 2003-2012.Epidemiology and infection · 2016Article
- Disruption of Skin Stem Cell Homeostasis following Transplacental Arsenicosis; Alleviation by Combined Intake of Selenium and Curcumin.PloS one · 2015Article
- In utero and early life arsenic exposure in relation to long-term health and disease.Toxicology and applied pharmacology · 2013Review
- Infant toenails as a biomarker of in utero arsenic exposure.Journal of exposure science & environmental epidemiologyArticle
- Placental arsenic concentrations in relation to both maternal and infant biomarkers of exposure in a US cohort.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArsenic in drinking water was associated with increased risk of all-cause, cancer, and cardiovascular death in adults. However, the extent to which exposure is related to all-cause and deaths from cancer and cardiovascular condition in young age is unknown. Therefore, we prospectively assessed whether long-term and recent arsenic exposures are associated with all-cause and cancer and cardiovascular mortalities in Bangladeshi childhood population. METHODS AND
findingsWe assembled a cohort of 58406 children aged 5-18 years from the Health and Demographic Surveillance System of icddrb in Bangladesh and followed during 2003-2010. There were 185 non-accidental deaths registered in-about 0.4 million person-years of observation. We calculated hazard ratios for cause-specific death in relation to exposure at baseline (µg/L), time-weighted lifetime average (µg/L) and cumulative concentration (µg-years/L). After adjusting covariates, hazard ratios (HRs) for all-cause childhood deaths comparing lifetime average exposure 10-50.0, 50.1-150.0, 150.1-300.0 and ≥300.1µg/L were 1.37 (95% confidence interval [CI], 0.74-2.57), 1.44 (95% CI, 0.88-2.38), 1.22 (95% CI, 0.75-1.98) and 1.88 (95% CI, 1.14-3.10) respectively. Significant increased risk was also observed for baseline (P for trend = 0.023) and cumulative exposure categories (P for trend = 0.036). Girls had higher mortality risk compared to boys (HR for girls 1.79, 1.21, 1.64, 2.31; HR for boys 0.52, 0.53, 1.14, 0.99) in relation to baseline exposure. For all cancers and cardiovascular deaths combined, multivariable adjusted HRs amounted to 1.53 (95% CI 0.51-4.57); 1.29 (95% CI 0.43-3.87); 2.18 (95%CI 1.15-4.16) for 10.0-50.0, 50.1-150.0, and ≥150.1, comparing lowest exposure as reference (P for trend = 0.009). Adolescents had higher mortality risk compared to children (HRs = 1.53, 95% CI 1.03-2.28 vs. HRs = 1.30, 95% CI 0.78-2.17).
conclusionsArsenic exposure was associated with substantial increased risk of deaths at young age from all-cause, and cancers and cardiovascular conditions. Girls and adolescents (12-18 years) had higher risk compared to boys and child.
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