ArticlePloS one2013
The star-nosed mole reveals clues to the molecular basis of mammalian touch.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Comparative Genomics Provides Insights into Adaptive Evolution in Tactile-Foraging Birds.Genes · 2022Article
- A bibliometric analysis and review of recent researches on Piezo (2010-2020).Channels (Austin, Tex.) · 2021Review
- Lamellar cells in Pacinian and Meissner corpuscles are touch sensors.Science advances · 2020Article
- Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization.Frontiers in cell and developmental biology · 2020Review
- A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds.Cell reports · 2019Article
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- S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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- Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice.Nature communications · 2018Article
- Molecular basis of tactile specialization in the duck bill.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.ACS chemical neuroscience · 2017Article
- Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.Trends in biochemical sciences · 2017Review
- Article
- Phospholipase C δ4 regulates cold sensitivity in mice.The Journal of physiology · 2016Article
- Evolutionary Specialization of Tactile Perception in Vertebrates.Physiology (Bethesda, Md.) · 2016Review
- Phosphoinositide signaling in somatosensory neurons.Advances in biological regulation · 2016Review
- Mammalian touch catches up.Current opinion in neurobiology · 2015Review
- Molecular mechanisms of temperature adaptation.The Journal of physiology · 2015Review
- HTR7 Mediates Serotonergic Acute and Chronic Itch.Neuron · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most sensitive tactile organs in the animal kingdom, the star of the star-nosed mole. Our findings demonstrate that the trigeminal ganglia innervating the star are enriched in tactile-sensitive neurons, resulting in a higher proportion of light touch fibers and lower proportion of nociceptors compared to the dorsal root ganglia innervating the rest of the body. We exploit this difference using transcriptome analysis of the star-nosed mole sensory ganglia to identify novel candidate mammalian touch and pain transducers. The most enriched candidates are also expressed in mouse somatosesensory ganglia, suggesting they may mediate transduction in diverse species and are not unique to moles. These findings highlight the utility of examining diverse and specialized species to address fundamental questions in mammalian biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.