ArticlePloS one2013
Role of neural stem cell activity in postweaning development of the sexually dimorphic nucleus of the preoptic area in rats.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- A Working Module for the Neurovascular Unit in the Sexually Dimorphic Nucleus of the Preoptic Area.Molecular neurobiology · 2018Article
- Estrogen Selectively Mobilizes Neural Stem Cells in the Third Ventricle Stem Cell Niche of Postnatal Day 21 Rats.Molecular neurobiology · 2015Article
- Cell death in the central division of the medial preoptic nucleus of male and female lamb fetuses.Brain research · 2014Article
- Development of the sexually dimorphic nucleus of the preoptic area and the influence of estrogen-like compounds.Neural regeneration research · 2013Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The sexually dimorphic nucleus of the preoptic area (SDN-POA) has received increased attention due to its apparent sensitivity to estrogen-like compounds found in food and food containers. The mechanisms that regulate SDN-POA volume remain unclear as is the extent of postweaning development of the SDN-POA. Here we demonstrate that the female Sprague-Dawley SDN-POA volume increased from weaning to adulthood, although this increase was not statistically significant as it was in males. The number of cells positive for Ki67, a marker of cell proliferation, in both the SDN-POA and the hypothalamus was significantly higher at weaning than at adulthood in male rats. In contrast, the number of Ki67-positive cells was significantly higher in the hypothalamus but not in the SDN-POA (p>0.05) at weaning than at adulthood in female rats. A subset of the Ki67-positive cells in the SDN-POA displayed the morphology of dividing cells. Nestin-immunoreactivity delineated a potential macroscopic neural stem cell niche in the rostral end of the 3rd ventricle. In conclusion, stem cells may partially account for the sexually dimorphic postweaning development of the SDN-POA.
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Registered trials
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