ArticlePloS one2013
Identification and characterization of Crr1a, a gene for resistance to clubroot disease (Plasmodiophora brassicae Woronin) in Brassica rapa L.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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108 citing papers in PubMed, 199 citations in OpenAlex.
- RNAI-based strategies and nanomaterial-mediated delivery for green control of clubroot disease in rapeseed.Journal of advanced research · 2026Article
- Recent progress in DNA marker-assisted selection for vegetable breeding in Japan.Breeding science · 2026Article
- Aesculetin-mediated recruitment of denitrifying microbiota by resistant rapeseed suppresses Plasmodiophora brassicae via nitrate depletion.The ISME journal · 2026Article
- Identification of candidate genes involved in root gall formation during early infection ofFrontiers in plant science · 2026Article
- A novel and efficient method for producing high-purity single protoplast-derived isolates ofFrontiers in microbiology · 2026Article
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- Genetic and Epigenetic Mechanisms Underpinning Biotic Stress Resilience ofPlants (Basel, Switzerland) · 2025Review
- Identification and characterization ofHorticulture research · 2025Article
- Inactivation of β-1,3-glucan synthase-like 5 confers broad-spectrum resistance to Plasmodiophora brassicae pathotypes in cruciferous plants.Nature genetics · 2025Article
- Article
- Identification of Rcr12, a single dominant clubroot resistance gene near Rcr6 on chromosome B3 of Brassica nigra.BMC plant biology · 2025Article
- Clubroot resistant in cruciferous crops: recent advances in genes and QTLs identification and utilization.Horticulture research · 2025Article
- Resistance gene enrichment sequencing refines the Brassica napus NLRome.Plant physiology · 2025Article
- A chromosome-level reference genome facilitates the discovery of clubroot-resistant geneHorticulture research · 2025Article
- Rapid introgression of the clubroot resistance geneMolecular breeding : new strategies in plant improvement · 2025Article
- Identification of three novel QTL for resistance to highly aggressive Canadian strains ofFrontiers in plant science · 2025Article
- Genetic improvement of clubroot resistance in the recessive genic male sterile line YA001 inFrontiers in plant science · 2025Article
- Genetic Mapping and Characterization of the Clubroot Resistance GeneInternational journal of molecular sciences · 2024Article
- Comparative Analysis of Transcriptomes Reveals Pathways and Verifies Candidate Genes for Clubroot Resistance inInternational journal of molecular sciences · 2024Article
- Optimizing Clubroot Management and the Role of Canola Cultivar Mixtures.Pathogens (Basel, Switzerland) · 2024Review
48 more citing papers are in PubMed but not listed here.
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Clubroot disease, caused by the obligate biotrophic protist Plasmodiophora brassicae Woronin, is one of the most economically important diseases of Brassica crops in the world. Although many clubroot resistance (CR) loci have been identified through genetic analysis and QTL mapping, the molecular mechanisms of defense responses against P. brassicae remain unknown. Fine mapping of the Crr1 locus, which was originally identified as a single locus, revealed that it comprises two gene loci, Crr1a and Crr1b. Here we report the map-based cloning and characterization of Crr1a, which confers resistance to clubroot in Brassica rapa. Crr1a(G004), cloned from the resistant line G004, encodes a Toll-Interleukin-1 receptor/nucleotide-binding site/leucine-rich repeat (TIR-NB-LRR) protein expressed in the stele and cortex of hypocotyl and roots, where secondary infection of the pathogen occurs, but not in root hairs, where primary infection occurs. Gain-of-function analysis proved that Crr1a(G004) alone conferred resistance to isolate Ano-01 in susceptible Arabidopsis and B. rapa. In comparison, the susceptible allele Crr1a(A9709) encodes a truncated NB-LRR protein, which lacked more than half of the TIR domain on account of the insertion of a solo-long terminal repeat (LTR) in exon 1 and included several substitutions and insertion-deletions in the LRR domain. This study provides a basis for further molecular analysis of defense mechanisms against P. brassicae and will contribute to the breeding of resistant cultivars of Brassica vegetables by marker-assisted selection.Data deposition The sequence reported in this paper has been deposited in the GenBank database (accession no. AB605024).
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