ArticlePloS one2013
Signal balancing by the CetABC and CetZ chemoreceptors controls energy taxis in Campylobacter jejuni.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Motility related gene expression of Campylobacter jejuni NCTC 11168 derived from high viscous media.European journal of microbiology & immunology · 2023Article
- Azospirillum brasilense AerC and Tlp4b Cytoplasmic Chemoreceptors Are Promiscuous and Interact with the Two Membrane-Bound Chemotaxis Signaling Clusters Mediating Chemotaxis Responses.Journal of bacteriology · 2023Article
- Polar localization of CheO under hypoxia promotes Campylobacter jejuni chemotactic behavior within host.PLoS pathogens · 2022Article
- A Review of the Advantages, Disadvantages and Limitations of Chemotaxis Assays forInternational journal of molecular sciences · 2022Review
- Genome-Wide Identification of Host-Segregating Single-Nucleotide Polymorphisms for Source Attribution of Clinical Campylobacter coli Isolates.Applied and environmental microbiology · 2020Article
- Article
- Unexpected differential metabolic responses of Campylobacter jejuni to the abundant presence of glutamate and fucose.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- The transducer-like protein Tlp12 of Campylobacter jejuni is involved in glutamate and pyruvate chemotaxis.BMC microbiology · 2018Article
- CapC, a Novel Autotransporter and Virulence Factor of Campylobacter jejuni.Applied and environmental microbiology · 2018Article
- Characterization of Swedish Campylobacter coli clade 2 and clade 3 water isolates.MicrobiologyOpen · 2018Article
- The Novel Protein Cj0371 Inhibits Chemotaxis ofFrontiers in microbiology · 2018Article
- Transducer-Like Protein inFrontiers in microbiology · 2018Article
- Sensory Repertoire of Bacterial Chemoreceptors.Microbiology and molecular biology reviews : MMBR · 2017Review
- Campylobacter jejuni transducer like proteins: Chemotaxis and beyond.Gut microbes · 2017Review
- Influence of haem environment on the catalytic properties of the tetrathionate reductase TsdA from Campylobacter jejuni.Bioscience reports · 2016Article
- Association ofEuropean journal of microbiology & immunology · 2016Article
- NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Campylobacter jejuni CsrA Regulates Metabolic and Virulence Associated Proteins and Is Necessary for Mouse Colonization.PloS one · 2016Article
- Conservation of σ28-Dependent Non-Coding RNA Paralogs and Predicted σ54-Dependent Targets in Thermophilic Campylobacter Species.PloS one · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The coupling of environmental sensing to flagella-mediated directed motility allows bacteria to move to optimum environments for growth and survival, either by sensing external stimuli (chemotaxis) or monitoring internal metabolic status (energy taxis). Sensing is mediated by transducer-like proteins (Tlp), either located in the membrane or in the cytoplasm, which commonly influence motility via the CheA-CheY chemotaxis pathway. In this study we have investigated the role of PAS-domain-containing intracellular Tlp-sensors in energy taxis of the food-borne pathogen Campylobacter jejuni, using plate- and tube-based assays utilising the conversion of the redox indicator dyes triphenyl tetrazolium chloride (TTC) and resazurin. Inactivation of the genes encoding the Campylobacter Energy Taxis system (CetA (Tlp9) and CetB (Aer2)) in C. jejuni strain NCTC 11168 resulted in reduced taxis. Inactivation of the cj1191c gene, encoding the CetB homolog CetC (Aer1), did not affect taxis per se, but the cetC gene complemented a cetB mutant in trans, indicating that CetC can form a functional signal transduction complex with CetA in the absence of CetB. Inactivation of both CetB and CetC resulted in greatly reduced taxis confirming the role of CetC in energy taxis. Inactivation of the cj1110c gene, encoding Tlp8 (CetZ), a cytoplasmic sensor with two PAS-domains, resulted in increased taxis, a phenotype opposite to that of CetAB. Inactivation of the cheA gene resulted in the same overall phenotype as the cetAB mutant in both wild-type and cetZ backgrounds, suggesting that both systems use the CheA system for signal transduction. Absence of both CetAB and CetZ resulted in the cetAB taxis phenotype, suggesting that CetZ is subordinate to CetAB. In conclusion, we present evidence that C. jejuni balances the input from two counteracting PAS-domain-containing sensory systems to position itself for optimal usage of energy resources.
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