ArticlePloS one2013
Chemoreceptors of Escherichia coli CFT073 play redundant roles in chemotaxis toward urine.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Death and chemotaxis: Bacterial chemotaxis enables collective escape from phage predation.Science advances · 2026Article
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- Phenotypic Assessment of Clinical Escherichia coli Isolates as an Indicator for Uropathogenic Potential.mSystems · 2022Article
- The Interaction of RecA With Both CheA and CheW Is Required for Chemotaxis.Frontiers in microbiology · 2020Article
- Novel Selective Detection Method of Tumor Angiogenesis Factors Using Living Nano-Robots.Sensors (Basel, Switzerland) · 2017Article
- Campylobacter jejuni transducer like proteins: Chemotaxis and beyond.Gut microbes · 2017Review
- Coordination of Metabolism and Virulence Factors Expression of Extraintestinal Pathogenic Escherichia coli Purified from Blood Cultures of Patients with Sepsis.Molecular & cellular proteomics : MCP · 2016Article
- SOS System Induction Inhibits the Assembly of Chemoreceptor Signaling Clusters in Salmonella enterica.PloS one · 2016Article
- Transducer like proteins of Campylobacter jejuni 81-176: role in chemotaxis and colonization of the chicken gastrointestinal tract.Frontiers in cellular and infection microbiology · 2015Article
- Architecture and signal transduction mechanism of the bacterial chemosensory array: progress, controversies, and challenges.Current opinion in structural biology · 2014Review
- Increasing and decreasing the ultrastability of bacterial chemotaxis core signaling complexes by modifying protein-protein contacts.Biochemistry · 2014Article
- RecA protein plays a role in the chemotactic response and chemoreceptor clustering of Salmonella enterica.PloS one · 2014Article
- Article
- Chemoreceptor gene loss and acquisition via horizontal gene transfer in Escherichia coli.Journal of bacteriology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Community-acquired urinary tract infections (UTIs) are commonly caused by uropathogenic Escherichia coli (UPEC). We hypothesize that chemotaxis toward ligands present in urine could direct UPEC into and up the urinary tract. Wild-type E. coli CFT073 and chemoreceptor mutants with tsr, tar, or aer deletions were tested for chemotaxis toward human urine in the capillary tube assay. Wild-type CFT073 was attracted toward urine, and Tsr and Tar were the chemoreceptors mainly responsible for mediating this response. The individual components of urine including L-amino acids, D-amino acids and various organic compounds were also tested in the capillary assay with wild-type CFT073. Our results indicate that CFT073 is attracted toward some L- amino acids and possibly toward some D-amino acids but not other common compounds found in urine such as urea, creatinine and glucuronic acid. In the murine model of UTI, the loss of any two chemoreceptors did not affect the ability of the bacteria to compete with the wild-type strain. Our data suggest that the presence of any strong attractant and its associated chemoreceptor might be sufficient for colonization of the urinary tract and that amino acids are the main chemoattractants for E. coli strain CFT073 in this niche.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.