ArticlePloS one2013
Inherited variants in regulatory T cell genes and outcome of ovarian cancer.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The associations between immunity-related genes and breast cancer prognosis in Korean women.PloS one · 2014Pooled it
- Into the future: A pilot study combining imaging with molecular profiling to predict resectability in ovarian cancer.Gynecologic oncology · 2022Article
- Regulation of regulatory T cells in cancer.Immunology · 2019Review
- Pooled Clustering of High-Grade Serous Ovarian Cancer Gene Expression Leads to Novel Consensus Subtypes Associated with Survival and Surgical Outcomes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.Oncotarget · 2016Article
- Drug discovery using clinical outcome-based Connectivity Mapping: application to ovarian cancer.BMC genomics · 2016Article
- Expression signature distinguishing two tumour transcriptome classes associated with progression-free survival among rare histological types of epithelial ovarian cancer.British journal of cancer · 2016Article
- Regulatory T cells, inherited variation, and clinical outcome in epithelial ovarian cancer.Cancer immunology, immunotherapy : CII · 2015Article
- Targeted immune therapy of ovarian cancer.Cancer metastasis reviews · 2015Review
- B7-H6 expression correlates with cancer progression and patient's survival in human ovarian cancer.International journal of clinical and experimental pathology · 2015Article
- Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.Journal of immunology research · 2015Review
- Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome.Cancer immunology research · 2014Article
- Toward understanding the genetics of regulatory T cells in ovarian cancer.Oncoimmunology · 2013Article
Corrections and comments
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Authors and funding
41 authors at 15 institutions in 2 countries.
Funding
Abstract
Although ovarian cancer is the most lethal of gynecologic malignancies, wide variation in outcome following conventional therapy continues to exist. The presence of tumor-infiltrating regulatory T cells (Tregs) has a role in outcome of this disease, and a growing body of data supports the existence of inherited prognostic factors. However, the role of inherited variants in genes encoding Treg-related immune molecules has not been fully explored. We analyzed expression quantitative trait loci (eQTL) and sequence-based tagging single nucleotide polymorphisms (tagSNPs) for 54 genes associated with Tregs in 3,662 invasive ovarian cancer cases. With adjustment for known prognostic factors, suggestive results were observed among rarer histological subtypes; poorer survival was associated with minor alleles at SNPs in RGS1 (clear cell, rs10921202, p=2.7×10(-5)), LRRC32 and TNFRSF18/TNFRSF4 (mucinous, rs3781699, p=4.5×10(-4), and rs3753348, p=9.0×10(-4), respectively), and CD80 (endometrioid, rs13071247, p=8.0×10(-4)). Fo0r the latter, correlative data support a CD80 rs13071247 genotype association with CD80 tumor RNA expression (p=0.006). An additional eQTL SNP in CD80 was associated with shorter survival (rs7804190, p=8.1×10(-4)) among all cases combined. As the products of these genes are known to affect induction, trafficking, or immunosuppressive function of Tregs, these results suggest the need for follow-up phenotypic studies.
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