ArticlePloS one2013
MR diffusion tensor imaging detects rapid microstructural changes in amygdala and hippocampus following fear conditioning in mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers.Human brain mapping · 2018Trial
- Alterations in gray matter microstructure and functional connectivity after acute stress.European journal of psychotraumatology · 2026Article
- Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-in-Schizophrenia 1 (DISC1).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Motor network pre-habilitation by low-frequency repetitive transcranial magnetic stimulation. A proof-of-concept.Acta neurochirurgica · 2025Article
- Detection of endophenotypes associated with neuropsychiatric deficiencies in a mouse model of tuberous sclerosis complex using diffusion tensor imaging.Brain pathology (Zurich, Switzerland) · 2021Article
- Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder.International journal of molecular sciences · 2020Review
- Conditioned Contextual Freezing is A Neurobehavioral Biomarker of Axonal Injury Indicated by Reduced Fractional Anisotropy in A Mouse Model of Blast-Induced Mild Traumatic Brain Injury.Shock (Augusta, Ga.) · 2020Article
- Stress-Induced Microstructural Alterations Correlate With the Cognitive Performance of Rats: A LongitudinalFrontiers in neuroscience · 2020Article
- Large-scale white matter network reorganization in posttraumatic stress disorder.Human brain mapping · 2019Article
- Body image disturbances, fear and associations with the amygdala in anorexia nervosa.Wiener klinische Wochenschrift · 2019Article
- High resolution isotropic diffusion imaging in post-mortem neonates: a feasibility study.The British journal of radiology · 2018Article
- White matter correlates of psychopathic traits in a female community sample.Social cognitive and affective neuroscience · 2017Article
- White matter changes in microstructure associated with a maladaptive response to stress in rats.Translational psychiatry · 2017Article
- Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.Translational psychiatry · 2016Article
- Treatment Outcome-Related White Matter Differences in Veterans with Posttraumatic Stress Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Structural and Functional Brain Remodeling during Pregnancy with Diffusion Tensor MRI and Resting-State Functional MRI.PloS one · 2015Article
- Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- In vivo quantitative whole-brain diffusion tensor imaging analysis of APP/PS1 transgenic mice using voxel-based and atlas-based methods.Neuroradiology · 2013Article
- Increased hippocampal volume and gene expression following cognitive behavioral therapy in PTSD.Frontiers in human neuroscience · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFollowing fear conditioning (FC), ex vivo evidence suggests that early dynamics of cellular and molecular plasticity in amygdala and hippocampal circuits mediate responses to fear. Such altered dynamics in fear circuits are thought to be etiologically related to anxiety disorders including posttraumatic stress disorder (PTSD). Consistent with this, neuroimaging studies of individuals with established PTSD in the months after trauma have revealed changes in brain regions responsible for processing fear. However, whether early changes in fear circuits can be captured in vivo is not known.
methodsWe hypothesized that in vivo magnetic resonance diffusion tensor imaging (DTI) would be sensitive to rapid microstructural changes elicited by FC in an experimental mouse PTSD model. We employed a repeated measures paired design to compare in vivo DTI measurements before, one hour after, and one day after FC-exposed mice (n=18).
resultsUsing voxel-wise repeated measures analysis, fractional anisotropy (FA) significantly increased then decreased in amygdala, decreased then increased in hippocampus, and was increasing in cingulum and adjacent gray matter one hour and one day post-FC respectively. These findings demonstrate that DTI is sensitive to early changes in brain microstructure following FC, and that FC elicits distinct, rapid in vivo responses in amygdala and hippocampus.
conclusionsOur results indicate that DTI can detect rapid microstructural changes in brain regions known to mediate fear conditioning in vivo. DTI indices could be explored as a translational tool to capture potential early biological changes in individuals at risk for developing PTSD.
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