ArticlePloS one2013
The mechanism of effective electroacupuncture on T cell response in rats with experimental autoimmune encephalomyelitis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis.Journal of neuroinflammation · 2025Article
- Mobilizing endogenous neuroprotection: the mechanism of the protective effect of acupuncture on the brain after stroke.Frontiers in neuroscience · 2024Review
- Moxibustion for Primary Dysmenorrhea: An Adjuvant Therapy for Pain Relief.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation.Neural regeneration research · 2021Review
- Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone-Induced Demyelinating Model.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation.Evidence-based complementary and alternative medicine : eCAM · 2019Article
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- Electro-acupuncture at Acupoint ST36 Ameliorates Inflammation and Regulates Th1/Th2 Balance in Delayed-Type Hypersensitivity.Inflammation · 2017Article
- Electroacupuncture Promotes Remyelination after Cuprizone Treatment by Enhancing Myelin Debris Clearance.Frontiers in neuroscience · 2016Article
- Moxibustion and Acupuncture Ameliorate Crohn's Disease by Regulating the Balance between Th17 and Treg Cells in the Intestinal Mucosa.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Acupuncture and multiple sclerosis: a review of the evidence.Evidence-based complementary and alternative medicine : eCAM · 2014Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we demonstrated that electroacupuncture (EA) decreased lymphocyte infiltration into the spinal cords of rats presenting with experimental autoimmune encephalomyelitis (EAE), a disease model used in the study of multiple sclerosis (MS). The aim of this study was to characterize the effects of EA on the EAE. Female Lewis rats were divided into either CFA, EAE, EA, or injection with naloxone after electroacupuncture (NAL) groups. Electroacupuncture was administered every day for 21 days. To evaluate proliferation and apoptosis, lymphocytes from rats presenting with EAE were collected and cultured with β-endorphin. Immunohistochemisty, flow cytometry and radio-immunity methods were applied to detect the expression of β-endorphin. Results presented in this report demonstrate that the beneficial anti-inflammatory effects of EA on EAE were related to β-endorphin production that balances the Thl/Th2 and Th17/Treg responses. These results suggest that β-endorphin could be an important component in the development of EA-based therapies used for the treatment of EAE.
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