ReviewTheranostics2012
Phase-change nanoparticles using highly volatile perfluorocarbons: toward a platform for extravascular ultrasound imaging.
Review in Theranostics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 134 citations in OpenAlex.
- Acoustically Activatable Drug-Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Phase-change perfluorocarbon nanodroplets enable spatiotemporal control of ultrasound and photoacoustic imaging and therapy.Biomedical engineering letters · 2026Review
- Thermally Activated Vaporization of Fluorocarbon-In-Hydrocarbon Exoskeletal Droplets.ACS omega · 2026Article
- Radiation induced vaporization of exoskeletal droplets as potential x-ray acoustic contrast agents.Medical physics · 2025Article
- Size matters: Micro- versus nanobubbles in ultrasound imaging and therapy.Science advances · 2025Article
- aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound.Journal of nanobiotechnology · 2025Article
- The radial dynamics and acoustic emissions of phase-shift droplets are impacted by mechanical properties of tissue-mimicking hydrogels.Ultrasonics sonochemistry · 2024Article
- Article
- Real-time spatiotemporal characterization of mechanics and sonoporation of acoustic droplet vaporization in acoustically responsive scaffolds.Applied physics letters · 2023Article
- Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions.Zeitschrift fur medizinische Physik · 2023Review
- Thermal and Acoustic Stabilization Of Volatile Phase-Change Contrast Agents Via Layer-By-Layer Assembly.Ultrasound in medicine & biology · 2023Article
- Acoustic Detection of Retained Perfluoropropane Droplets Within the Developing Myocardial Infarct Zone.Ultrasound in medicine & biology · 2022Article
- Perfluorocarbon nanodroplet size, acoustic vaporization, and inertial cavitation affected by lipid shell composition in vitro.The Journal of the Acoustical Society of America · 2022Article
- Activation of Phase Change Contrast Agents Using Ionizing Radiation.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022Article
- Selective Enhancement of Swine Myocardium with a Novel Ultrasound Enhancing Agent During Transthoracic Echocardiography.Journal of cardiovascular translational research · 2022Article
- Slow-Flow Ultrasound Localization Microscopy Using Recondensation of Perfluoropentane Nanodroplets.Ultrasound in medicine & biology · 2022Article
- Effect of perfluorocarbon composition on activation of phase-changing ultrasound contrast agents.Medical physics · 2022Article
- Ultrasound contrast agents: microbubbles made simple for the pediatric radiologist.Pediatric radiology · 2021Review
- Stable Thermally-Modulated Nanodroplet Ultrasound Contrast Agents.Nanomaterials (Basel, Switzerland) · 2021Article
- Delayed Echo Enhancement Imaging to Quantify Myocardial Infarct Size.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Recent efforts using perfluorocarbon (PFC) nanoparticles in conjunction with acoustic droplet vaporization has introduced the possibility of expanding the diagnostic and therapeutic capability of ultrasound contrast agents to beyond the vascular space. Our laboratories have developed phase-change nanoparticles (PCNs) from the highly volatile PFCs decafluorobutane (DFB, bp =-2 °C) and octafluoropropane (OFP, bp =-37 °C ) for acoustic droplet vaporization. Studies with commonly used clinical ultrasound scanners have demonstrated the ability to vaporize PCN emulsions with frequencies and mechanical indices that may significantly decrease tissue bioeffects. In addition, these contrast agents can be formulated to be stable at physiological temperatures and the perfluorocarbons can be mixed to modulate the balance between sensitivity to ultrasound and general stability. We herein discuss our recent efforts to develop finely-tuned diagnostic/molecular imaging agents for tissue interrogation. We discuss studies currently under investigation as well as potential diagnostic and therapeutic paradigms that may emerge as a result of formulating PCNs with low boiling point PFCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.