ArticlePLoS genetics2013
The flowering repressor SVP underlies a novel Arabidopsis thaliana QTL interacting with the genetic background.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 79 citations in OpenAlex.
- Molecular integration of seasonal temperature signals in flowering time control.Nature reviews. Genetics · 2026Review
- Integrating molecular networks and physiological adaptation for heat-resilient crops.Journal of integrative plant biology · 2026Review
- Analyses of gene families, allelic variation and VIGS reveal that GheIF3M.2 is significantly associated with dwarfism and the absence of flower buds in upland cotton.Functional & integrative genomics · 2025Article
- Ectopic Over-Expression ofPlants (Basel, Switzerland) · 2025Article
- Life-history trade-offs explain local adaptation inbioRxiv : the preprint server for biology · 2025Article
- Assisted Gene Flow Management to Climate Change in the Annual LegumeEvolutionary applications · 2025Article
- Flowering time: From physiology, through genetics to mechanism.Plant physiology · 2024Review
- Flowering genes identification, network analysis, and database construction for 837 plants.Horticulture research · 2024Article
- Responsiveness to long days for flowering is reduced in Arabidopsis by yearly variation in growing season temperatures.Plant, cell & environment · 2023Article
- The unequal functional redundancy of ArabidopsisFrontiers in plant science · 2023Article
- Natural variation of Dt2 determines branching in soybean.Nature communications · 2022Article
- The genome of Cymbidium sinense revealed the evolution of orchid traits.Plant biotechnology journal · 2021Article
- Quantitative Trait Loci and Candidate Genes Associated with Photoperiod Sensitivity in Lettuce (Lactuca spp.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Genome wide association analyses to understand genetic basis of flowering and plant height under three levels of nitrogen application in Brassica juncea (L.) Czern & Coss.Scientific reports · 2021Article
- Genetics of days to flowering, maturity and plant height in natural and derived forms of Brassica rapa L.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Flowering Times of WildFrontiers in plant science · 2021Article
- Identification and Characterization ofFrontiers in plant science · 2021Article
- A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila.Evolution; international journal of organic evolution · 2019Article
- Translating Flowering Time From Arabidopsis thaliana to Brassicaceae and Asteraceae Crop Species.Plants (Basel, Switzerland) · 2018Review
- Ambient Temperature-Responsive Mechanisms Coordinate Regulation of Flowering Time.International journal of molecular sciences · 2018Review
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The timing of flowering initiation is a fundamental trait for the adaptation of annual plants to different environments. Large amounts of intraspecific quantitative variation have been described for it among natural accessions of many species, but the molecular and evolutionary mechanisms underlying this genetic variation are mainly being determined in the model plant Arabidopsis thaliana. To find novel A. thaliana flowering QTL, we developed introgression lines from the Japanese accession Fuk, which was selected based on the substantial transgression observed in an F(2) population with the reference strain Ler. Analysis of an early flowering line carrying a single Fuk introgression identified Flowering Arabidopsis QTL1 (FAQ1). We fine-mapped FAQ1 in an 11 kb genomic region containing the MADS transcription factor gene SHORT VEGETATIVE PHASE (SVP). Complementation of the early flowering phenotype of FAQ1-Fuk with a SVP-Ler transgen demonstrated that FAQ1 is SVP. We further proved by directed mutagenesis and transgenesis that a single amino acid substitution in SVP causes the loss-of-function and early flowering of Fuk allele. Analysis of a worldwide collection of accessions detected FAQ1/SVP-Fuk allele only in Asia, with the highest frequency appearing in Japan, where we could also detect a potential ancestral genotype of FAQ1/SVP-Fuk. In addition, we evaluated allelic and epistatic interactions of SVP natural alleles by analysing more than one hundred transgenic lines carrying Ler or Fuk SVP alleles in five genetic backgrounds. Quantitative analyses of these lines showed that FAQ1/SVP effects vary from large to small depending on the genetic background. These results support that the flowering repressor SVP has been recently selected in A. thaliana as a target for early flowering, and evidence the relevance of genetic interactions for the intraspecific evolution of FAQ1/SVP and flowering time.
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